ID A0A367EU51_9ACTN Unreviewed; 502 AA.
AC A0A367EU51;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Hopanoid C-3 methylase HpnR {ECO:0000313|EMBL:RCG21259.1};
GN Name=hpnR {ECO:0000313|EMBL:RCG21259.1};
GN ORFNames=DTL70_17520 {ECO:0000313|EMBL:RCG21259.1};
OS Streptomyces diacarni.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2800381 {ECO:0000313|EMBL:RCG21259.1, ECO:0000313|Proteomes:UP000252914};
RN [1] {ECO:0000313|EMBL:RCG21259.1, ECO:0000313|Proteomes:UP000252914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW51701 {ECO:0000313|EMBL:RCG21259.1,
RC ECO:0000313|Proteomes:UP000252914};
RA Li L.;
RT "Streptomyces reniochalinae sp. nov. and Streptomyces diacarnus sp. nov.
RT from marine sponges.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCG21259.1}.
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DR EMBL; QOIN01000046; RCG21259.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367EU51; -.
DR OrthoDB; 5298546at2; -.
DR Proteomes; UP000252914; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR027564; HpnR_B12_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04367; HpnR_B12_rSAM; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF17; MG-PROTOPORPHYRIN IX MONOMETHYL ESTER OXIDATIVE CYCLASE 66KD SUBUNIT; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00565; hopanoid_C3-methyltransferase; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:RCG21259.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000252914};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:RCG21259.1}.
FT DOMAIN 8..141
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 180..394
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 502 AA; 56552 MW; C3028B45EB4E19DE CRC64;
MRLLLVHPSA LMYSEIFLRL EPLGLERVAA AARDAGHQVR VVDLQVLSPK LLERELRSFQ
PEALGISLNY LANIPEALEI AQSAKAAVPG CFVFFGGHSV SFIGDHVLEQ AEGAVDAIAR
GEGETVVVPL LAAVPDKAAH TVPGVVTAEG RGPAPKMLES IDAPRPARDL MRRRNRYFIG
ELDPCASIEF TRGCPWDCSF CSAWTFYGRS YRRAAPEAAA EEMASIREPN VFIVDDVAFI
KSDHGHGIAA ELERRNIRKQ YYLETRADVL LRNEEVFERW TKLGLRYMFL GMEALDADGL
DQFRKRISPD ENFRALETAR RLGISVAINL IVDPAWDEEQ FRLVREFALS VPEIVHLTVM
TPYPGTEVWH TESRQLTTRD YRLFDIQHAV VPTRLPLEQF YRELVRTQAV INRKHLGLST
AIGAMRILGR NLAHGQTNFA RMLWKFGRVY NANRQLSDHA REVRYELPLP ERRTAAPGRK
ELFVHTIGRT GARAQAGPTT PQ
//
