ID A0A367F5Q6_9ACTN Unreviewed; 277 AA.
AC A0A367F5Q6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:RCG25684.1};
GN ORFNames=DTL70_09015 {ECO:0000313|EMBL:RCG25684.1};
OS Streptomyces diacarni.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2800381 {ECO:0000313|EMBL:RCG25684.1, ECO:0000313|Proteomes:UP000252914};
RN [1] {ECO:0000313|EMBL:RCG25684.1, ECO:0000313|Proteomes:UP000252914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHW51701 {ECO:0000313|EMBL:RCG25684.1,
RC ECO:0000313|Proteomes:UP000252914};
RA Li L.;
RT "Streptomyces reniochalinae sp. nov. and Streptomyces diacarnus sp. nov.
RT from marine sponges.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCG25684.1}.
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DR EMBL; QOIN01000036; RCG25684.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367F5Q6; -.
DR OrthoDB; 9768793at2; -.
DR Proteomes; UP000252914; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd19138; AKR_YeaE; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000252914}.
FT DOMAIN 18..264
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 56
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 114
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 81
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 277 AA; 30141 MW; FCC9776C0F504EFA CRC64;
MHVIRTVTLP SGARVPALGQ GTWHMGDDPS RRAEELDALR TGLDLGMTLI DTAEMYGSGA
SEELVGEAIR GRRDEAFLVS KVLPSNADRR GTVEACRASL RRLGTDRIDL YLLHWRGGVP
LAETVEALEE LVRQGSIGSW GVSNLDTDDL ADLPRGAVPD TDQILYNLTR RGPEYALLPR
CRELSVPVMA YSPVEQGRLL GHEALRAIAD AHGATPAQVA LAWVLRHEEV IAIPKASSRR
HVEENRAAAD LVLGEEDFAA LDEAFPPPAG KRPLEIL
//
