ID   A0A367FKX7_9ACTN        Unreviewed;       662 AA.
AC   A0A367FKX7;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=DQ384_13450 {ECO:0000313|EMBL:RCG30954.1};
OS   Sphaerisporangium album.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Sphaerisporangium.
OX   NCBI_TaxID=509200 {ECO:0000313|EMBL:RCG30954.1, ECO:0000313|Proteomes:UP000253094};
RN   [1] {ECO:0000313|EMBL:RCG30954.1, ECO:0000313|Proteomes:UP000253094}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCTCC AA 208026 {ECO:0000313|EMBL:RCG30954.1,
RC   ECO:0000313|Proteomes:UP000253094};
RA   Li L.;
RT   "Sphaerisporangium craniellae sp. nov., isolated from a marine sponge in
RT   the South China Sea.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCG30954.1}.
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DR   EMBL; QOIL01000006; RCG30954.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A367FKX7; -.
DR   OrthoDB; 9784823at2; -.
DR   Proteomes; UP000253094; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR   PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Methyltransferase {ECO:0000313|EMBL:RCG30954.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253094};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   Transferase {ECO:0000313|EMBL:RCG30954.1}.
FT   DOMAIN          200..353
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   662 AA;  70308 MW;  4088DCDD9D4C8708 CRC64;
     MGHDAMLNAG DIARLADVGR AAVSNWRRRY DDFPQPVGGT AASPLFSLPE VEDWLRRNGK
     SYEMSLGDRV WQRLRASGDD LRLGERVGCA GAFLLYLRRD PGDWKNLART PELAELLPEA
     AAGATADLPV PVAWDLIDAR LYHLLADLAA EQGPAEAFEL LCERYVEAHS RQLSVTRPEI
     AGLLTRLALH DLRTTPGGDA GTAATVLDPA CGIGALLLPF GGARVLGQES GDTTALLTAV
     RLLLRGTHAE VVAGDSLRLD GFPRLRADVV VCDPPFNERA WGYEELTGDP RWEYGLPPRG
     EPELAWVQHC LAHVRPGGLV AILMPPAAAS RRPGKRIRGN LLRAGALRAV ITLQAGGPDL
     WLLRRPGPGE RPPSLVLLMD AASGPASAEA AQPSSLVEAA WRAFTTDPEA QPPGPCRAVR
     IIDLLDDEVD LGPARHLPLR ADEDPAAGFV AISERFRASA AELPGAPPSL GVLAEPRDLP
     STTVGELVRA GLLTIHQGPP KTTTGPGDVP VLTAADLAAG GPPSGRTSPD PGHVTLEPGD
     VVAAGATGEG AARTVTEGGA VLGPQLYLYR VDPERMDPDF LAGFLRYAGA WGSARSHPGA
     SRVDARRVRI PRLSLPEQQV YGKAFRELLD LEDRLRETAA LGEALIRLGF DGLVGGHLRP
     SG
//