ID A0A367JP20_RHIST Unreviewed; 961 AA.
AC A0A367JP20;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE Flags: Fragment;
GN Name=BRIP1_3 {ECO:0000313|EMBL:RCH91609.1};
GN ORFNames=CU098_005034 {ECO:0000313|EMBL:RCH91609.1};
OS Rhizopus stolonifer (Rhizopus nigricans).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=4846 {ECO:0000313|EMBL:RCH91609.1, ECO:0000313|Proteomes:UP000253551};
RN [1] {ECO:0000313|EMBL:RCH91609.1, ECO:0000313|Proteomes:UP000253551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSU 92-RS-03 {ECO:0000313|EMBL:RCH91609.1,
RC ECO:0000313|Proteomes:UP000253551};
RX PubMed=29674435; DOI=10.1534/g3.118.200235;
RA Gryganskyi A.P., Golan J., Dolatabadi S., Mondo S., Robb S., Idnurm A.,
RA Muszewska A., Steczkiewicz K., Masonjones S., Liao H.L., Gajdeczka M.T.,
RA Anike F., Vuek A., Anishchenko I.M., Voigt K., de Hoog G.S., Smith M.E.,
RA Heitman J., Vilgalys R., Stajich J.E.;
RT "Phylogenetic and Phylogenomic Definition of Rhizopus Species.";
RL G3 (Bethesda) 8:2007-2018(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCH91609.1}.
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DR EMBL; PJQM01002967; RCH91609.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367JP20; -.
DR STRING; 4846.A0A367JP20; -.
DR EnsemblFungi; RCH91609; RCH91609; CU098_005034.
DR Proteomes; UP000253551; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProt.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000253551}.
FT DOMAIN 1..202
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 673..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RCH91609.1"
SQ SEQUENCE 961 AA; 110455 MW; 5CB1CDAB7C87B72B CRC64;
EKAEKEFTKI PKIFVGSRTH KQITQLVQEL RSNTRYTART TILGSREQFC IHSKVSKSTT
KNDDCTELLD ENACSYFHKT RKLIAHAADK DNRIWDIEDL VELGNEVHGC PYFASRKIYE
FAEVVFCPYN YIIDPVIRAS MDIHLKDSIV ILDEAHNIED ASRSAGSFEI DENAVDVLLK
ELELVVKYGG EKEAHTIIEM VMANIKDFFT DSSTEYTIKE YEKQSGHWAG SAMMQKLHQI
NISPTTFRET LQPAYKTIVA HADLVRKEKE LKKETGAVFQ SDADDILNQE DNAEHRVVRL
QCLSNGSLRL VQGLFMVLGF LCDENHQYAE DYEMVLTKTL ERLKPKKKRR RRRQEEQEDQ
GPIWVHRIAF WCLNPGIIFR QMSQDTRSVI LTSGTLSPLN TFASELGTQF TGQLEANHVI
QSSQVWVGAI PQGPNRIQLK GIYSNLESFY YQDEVGDTLL EIVQTVPYGV LCFLPSYKAM
DILIDRWKLT GVMEKLQQRK QVLSEPKGSD KKEFESILNT FYHQIDTAVA GHDPDQRDGA
IFFAVFRGKV SEGIDFSDHY CRAVVTLGIP YPGVKDLEVK LKREYNNKRR MRQKDVLSGQ
EWYSAQAYRA INQALGRCIR HRNDWGAIIL LEERFCQQEV MNGLSKWVKG QFRVHSSYLA
AMSSLKQFVA RQMQGETTQQ NNASSLPTNN TLAPGPSETS EQSLADKERA DTDQDIEKGL
EDIQREMEAI QKEIDAEVFI KKETEHIEEK TEQHVEHIEQ HVEQKIEQDI QQEIEHIEQH
VEQKIEQDIQ QEIEHIEQKI APHAEQDTNE SMQDVQSVPQ KTELFVPNTI ISCKYCLKEL
ICGPDTLLSS VCDTQLQCLQ DSYNKPPVVQ LINPSSYWQI SSELLGGPLD IDQLPNCVPV
LYNRQDQVCY RLLASTIPDN TRHVGCVYLW ENKVKKLPLP SKELMDLSSQ QPSYMDDIFY
M
//
