ID A0A367JY17_RHIST Unreviewed; 513 AA.
AC A0A367JY17;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Elongator complex protein 4 {ECO:0000256|ARBA:ARBA00020265};
DE Flags: Fragment;
GN Name=ELP4 {ECO:0000313|EMBL:RCH94854.1};
GN ORFNames=CU098_001978 {ECO:0000313|EMBL:RCH94854.1};
OS Rhizopus stolonifer (Rhizopus nigricans).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=4846 {ECO:0000313|EMBL:RCH94854.1, ECO:0000313|Proteomes:UP000253551};
RN [1] {ECO:0000313|EMBL:RCH94854.1, ECO:0000313|Proteomes:UP000253551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSU 92-RS-03 {ECO:0000313|EMBL:RCH94854.1,
RC ECO:0000313|Proteomes:UP000253551};
RX PubMed=29674435; DOI=10.1534/g3.118.200235;
RA Gryganskyi A.P., Golan J., Dolatabadi S., Mondo S., Robb S., Idnurm A.,
RA Muszewska A., Steczkiewicz K., Masonjones S., Liao H.L., Gajdeczka M.T.,
RA Anike F., Vuek A., Anishchenko I.M., Voigt K., de Hoog G.S., Smith M.E.,
RA Heitman J., Vilgalys R., Stajich J.E.;
RT "Phylogenetic and Phylogenomic Definition of Rhizopus Species.";
RL G3 (Bethesda) 8:2007-2018(2018).
CC -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC biosynthesis. {ECO:0000256|ARBA:ARBA00005043}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ELP4 family.
CC {ECO:0000256|ARBA:ARBA00007573}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCH94854.1}.
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DR EMBL; PJQM01002506; RCH94854.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367JY17; -.
DR STRING; 4846.A0A367JY17; -.
DR EnsemblFungi; RCH94854; RCH94854; CU098_001978.
DR UniPathway; UPA00988; -.
DR Proteomes; UP000253551; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033588; C:elongator holoenzyme complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd19494; Elp4; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008728; Elongator_complex_protein_4.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001388; Synaptobrevin-like.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR12896:SF1; ELONGATOR COMPLEX PROTEIN 4; 1.
DR PANTHER; PTHR12896; PAX6 NEIGHBOR PROTEIN PAXNEB; 1.
DR Pfam; PF05625; PAXNEB; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253551};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 495..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 433..493
FT /note="V-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50892"
FT REGION 367..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 513
FT /evidence="ECO:0000313|EMBL:RCH94854.1"
SQ SEQUENCE 513 AA; 57468 MW; 5FD399B62E8C6934 CRC64;
MSFKKRNAEQ QPKLPSGTRL SAYNGQLLIS TGVPSLDDIL GGGQPVGTIM LIKEDRATTY
AQLLLKYFIA QGIASGHHCA VTSRDEDPEE MLRTLMWLSN QDKDDDDDNI KNSQTEGESD
RMKIAWRYSH LKRLEGGVKP KPASPVSVKP TIEQDNKNIE EPKPYCSQFD LTKRISKEAL
EEAKMDILQW DYQGDEDYKT LIDQVRKVVL EGNFSSAVPV APGTPRNALR LAIHSIASPS
WQSQSPHDLY KFFHALRGLL RFSFGTAMIT IPAHLYDEEP QFIKRIEYMV DAVIEIESFA
GDPVHNEAAY TQNYHGFFHV HKLPVLNSLL PPSTKLSVLS GGGSNDLGFK LRRKRFAIET
FHLPPEGGVV TRRTEAPSTK EEEEAPKGNI TSSLASRGPK KIGCGSTPGR TDPLESQPYD
PYSPTQGGQN TNKTTQVQHQ VDEVVGIMQQ NIDKAMQRGE RIDDLRGRTE DLQGTAGHFR
RGANQVRKRM WWKDLKWKIV IAIVIIAILG III
//
