ID A0A367KLD2_RHIST Unreviewed; 1212 AA.
AC A0A367KLD2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Ras GTPase activating protein ira2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=CU098_004255 {ECO:0000313|EMBL:RCI02950.1};
OS Rhizopus stolonifer (Rhizopus nigricans).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=4846 {ECO:0000313|EMBL:RCI02950.1, ECO:0000313|Proteomes:UP000253551};
RN [1] {ECO:0000313|EMBL:RCI02950.1, ECO:0000313|Proteomes:UP000253551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSU 92-RS-03 {ECO:0000313|EMBL:RCI02950.1,
RC ECO:0000313|Proteomes:UP000253551};
RX PubMed=29674435; DOI=10.1534/g3.118.200235;
RA Gryganskyi A.P., Golan J., Dolatabadi S., Mondo S., Robb S., Idnurm A.,
RA Muszewska A., Steczkiewicz K., Masonjones S., Liao H.L., Gajdeczka M.T.,
RA Anike F., Vuek A., Anishchenko I.M., Voigt K., de Hoog G.S., Smith M.E.,
RA Heitman J., Vilgalys R., Stajich J.E.;
RT "Phylogenetic and Phylogenomic Definition of Rhizopus Species.";
RL G3 (Bethesda) 8:2007-2018(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI02950.1}.
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DR EMBL; PJQM01001200; RCI02950.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367KLD2; -.
DR STRING; 4846.A0A367KLD2; -.
DR EnsemblFungi; RCI02950; RCI02950; CU098_004255.
DR Proteomes; UP000253551; Unassembled WGS sequence.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000253551}.
FT DOMAIN 87..193
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 561..789
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT NON_TER 1212
FT /evidence="ECO:0000313|EMBL:RCI02950.1"
SQ SEQUENCE 1212 AA; 140767 MW; 224C62337A404D8E CRC64;
MANYTPLNRL SNMAGKNGLL NLHIPTITED AEDVIGMQGF ETKKVYLFFA LLNNYLTGRI
RLQKDDKINT SQWMDKQRTN LLAYEYLCHI GEAKEWIEDC LQDEIDPITK LEETMRNGIV
LARLANWFAP GTAPKIFQDS KLQFRHSDNI NYFFDALEMI KLPQIFWFEL TDLYEKKNIP
KVIYCIHALS HLLARRNMAP NIKNLLGQLQ FTNEELMATQ RHLDMSGVPM PNFMNVGYSL
NRELNEGGEN DDYKYLQLES IPFNLKTPEL IIEEEEDSDL ESPDDMSPEA IKQYWEDEIT
LNKVVHCQRI ARSWISNREA QRKQNLYESF ELNALITRFQ AEARRMSAQK DLISRHQALN
SIDPGFVTRL QAQCRGCMRR LEYFSLLDYY HKNIDQVVKI QSFIKNKLVG NAYRRLTTEP
NPSLNTVKDF IHLLDDNDLD FDRELELESL RQEVIEYIRE NHMLESHVAS LDIQIALFLK
NAITIEEKKK ETERMMLTAA ANQQMSPFSL SGVDKESRQR LELFQQLVYV LQTEPHYVAR
LLSITNRQDL GHYSSHKLIE STVLSLFGYA TNAREEYLLI NLCKQCISEE LQHVESPQEF
MRGNYTFMKL VVQTNRGAKE RQFFRELFGD LIKQVVNNDF LDLELDLVNI YHKSINDEES
RTGMPSTRPH AVTAQDVSSD VDAIDTFARH LRTLREITEC FFNKITSTID EVPYGIRMVA
RELKRALEEK FEDEPSESIV KILGNFIYYR YLNPAIVAPE QYDVIDGIIS PMQRKNLAEI
SKMLQRIASG STFSGQDTLF LTLNDYLSYA SKRFADWFIT LTEVEDPETY FNMDSLTDQV
STIKPVVYLL PLELFHLHYT IQNNMDNIEP DGCGVLSEIV SDLGESAYHP DVTLPDTTVC
LSLSSPYDDL PMDHEAQLEQ LLVDAKRLVV YVIKIQSGPT LSRIFDQHIT IDQEKVWDQF
KYNEFLDIEE ENSAAAKRRY LRLGQADQPI DLRSLTFSQL KMLAHRLVAN LAYAKKLSEE
NDFQEIVTLI ARDITGKNTR RMQRDGEITR TKQTLSHLKE KREYLLDQGN QYEGYLNSCM
NAMANKRGKK QKFVFPFTRQ YFHIRGLQKL GSVPKFGSYK YTAKQLCDRN VLLEVMDIPK
KYYDRISIVL SMDQAGIITI EASYARWPMS SVLVDMRYEE LLQTQFEGAQ TMIVLDGMAK
VNVNLLIYLV NK
//
