ID A0A367KSQ8_RHIST Unreviewed; 1850 AA.
AC A0A367KSQ8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 03-MAY-2023, entry version 15.
DE RecName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00012589};
DE EC=2.4.1.34 {ECO:0000256|ARBA:ARBA00012589};
GN Name=FKS1_4 {ECO:0000313|EMBL:RCI05249.1};
GN ORFNames=CU098_010119 {ECO:0000313|EMBL:RCI05249.1};
OS Rhizopus stolonifer (Rhizopus nigricans).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=4846 {ECO:0000313|EMBL:RCI05249.1, ECO:0000313|Proteomes:UP000253551};
RN [1] {ECO:0000313|EMBL:RCI05249.1, ECO:0000313|Proteomes:UP000253551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSU 92-RS-03 {ECO:0000313|EMBL:RCI05249.1,
RC ECO:0000313|Proteomes:UP000253551};
RX PubMed=29674435; DOI=10.1534/g3.118.200235;
RA Gryganskyi A.P., Golan J., Dolatabadi S., Mondo S., Robb S., Idnurm A.,
RA Muszewska A., Steczkiewicz K., Masonjones S., Liao H.L., Gajdeczka M.T.,
RA Anike F., Vuek A., Anishchenko I.M., Voigt K., de Hoog G.S., Smith M.E.,
RA Heitman J., Vilgalys R., Stajich J.E.;
RT "Phylogenetic and Phylogenomic Definition of Rhizopus Species.";
RL G3 (Bethesda) 8:2007-2018(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:21476, Rhea:RHEA-
CC COMP:11146, Rhea:RHEA-COMP:14303, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37671, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000192};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 48 family.
CC {ECO:0000256|ARBA:ARBA00009040}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI05249.1}.
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DR EMBL; PJQM01000438; RCI05249.1; -; Genomic_DNA.
DR STRING; 4846.A0A367KSQ8; -.
DR EnsemblFungi; RCI05249; RCI05249; CU098_010119.
DR Proteomes; UP000253551; Unassembled WGS sequence.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IEA:InterPro.
DR GO; GO:0003843; F:1,3-beta-D-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IEA:InterPro.
DR InterPro; IPR026899; FKS1-like_dom1.
DR InterPro; IPR003440; Glyco_trans_48.
DR PANTHER; PTHR12741:SF29; 1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED; 1.
DR PANTHER; PTHR12741; LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1; 1.
DR Pfam; PF14288; FKS1_dom1; 1.
DR Pfam; PF02364; Glucan_synthase; 1.
DR SMART; SM01205; FKS1_dom1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253551};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1316..1341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1368..1389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1479..1503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1578..1595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1616..1649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1655..1676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1759..1788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1809..1835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 316..425
FT /note="1,3-beta-glucan synthase component FKS1-like"
FT /evidence="ECO:0000259|SMART:SM01205"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 986..1013
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1850 AA; 211463 MW; E736659CE4AA3721 CRC64;
MADKDPADHK DEGLTDQAKT TTNDRSEEIE SHPKDLEEIR AYYTDTVDDS TENKTFNTNR
LDQDNLDLPS PTIHMNIPTQ PTSEDNIIKN IQKNQTYTSS FETLSHRQRK NIYGTSSSTM
QPNQDAYDID ILASLADGDD GRYAKYASSA DSMMALLANT KYKGSQLPGE SHSSIGSQPL
NPQANGYATK DSPYPSWGPE AQIPITLKQV HSIFDGLAKA FGFQADSVKN IIEHLMTMLD
SRASRLIPQV ALDSLHADYI GGENSNYRKW FFASQMDLYD QTEEEKILAK DIGDEQELLS
RHQEKWLLRM QKLTNVEKTR DLALYLLLWG EAAPVRYTPE TLCFIYKMAS DYYTHPGTKP
DVAEGSFLDT IISPLYRFFR DQTYVLKDGR YVKRERDHDR VIGYDDVNQF FWYPTFYDQI
IVSADDRTRT LGKLPPHERY GALKDVNWDK TFKKTYKEKR TWMHASVNFS RVWVIHIVTF
WYYITANAYS IYLDTEKEIS DQEVSVQISI VALGGMVACL LVLIGSCAEL AYLPFSWGKS
KHLVRRVSFL LVLMVINTGP SFYCLVIDRL SWISKTVSVV QLLISVATTL FLAIVPPANL
FERKKKHTRV ELANEVFTSN FAPLKKIDRI MSICLWICVF TCKLLESYFF LALSFKDPLK
VISKMKVTNC NDRIIGTMLC EQMPRITIFI MLLMDLVLYF LDTYLWYIIW NTVFSVARSF
YLGISIWTPW RNIFCRLPKR IFVKLLATTD IHINDKPKLL CSQIWNAIVL TMYREHLITA
DHAQRMLYQQ ELNPLDGQRN LRSPTFFVSQ EDTSFKTEYF PQGGEAERRI HFFAQSLTTP
MPAPHPVQCM PTFTVLTPHY GEKILLSLRE IIREEDNNTR VTLLEYLKQL HPNEWENFVK
DTKILASDDE KSMGTSSTLH DSDFQDSQIK KLPKNDDLPF YCIGFKNSKP EYTLRTRIWA
SLRAQTLYRT VSGFMNYKKA IKLLYRVESS DQVKAYQSNK DKLEKDLDVL SRSKFKFLVA
MQRYAKFSKT ESEDSEFLFK AFPDLQVAYV DEAPSEIEGG ETTFYSALID GHSPIMENGK
RKPYFRIRLP GNPILGDGKS DNQNHAIIFY RGEFLQLIDA NQDNYLEECL KIRNVLGEFE
VLEPVQESPY SSGYVKHQAS PVAIVGAREY IFSENVGVLG DVAAGKEQTF GTLTQRIMAK
SGGKLHYGHP DFLNAIYMNT RGGVSKAQKG LHLNEDIYAG MNSFIRGGRI KHTEYFQCGK
GRDLGFGSIL NFTTKIGTGM GEQMLSREYY YIGTQLPLDR FLTFYYAHPG FHLNNIFIML
SVQIFMLAAL FISAMGASLT ICEYNADAPE DAPLIPLGCY NLVPIYDWVK RCILSIVAVF
LVAFLPLFLQ ELTEKGFWRS LTRIGKHFAS LSPLFEIFVT QIYTNSVLEN LVYGGARYIG
TGRGFATSRI SFATLYSRFT GPSIYVGARN FLIMLFASLA YWIPHLIYFW FTVVALIISP
FVFNPNQFAP VDFFVDYKEF IRWMSRGNSK THANSWISHT RASRARITGY KRSKATEATN
SIADIPRANK TAMILSEVIS PLLYAILCTI PYTFIKSFDT TDPTLPSTGP SGLIRIGVIA
LAPILLNMVG LMMFFGMSVG IGCVLSLWMN KFGSVMAALA HGWSVINLIV IFEVFFVLEE
WNLMHVALGL VAISSIQRFV LKLLTVLCLT REFKHDEVNR GWWTGKWYGR GLGWHAISQP
AREFVCKIIE MTEFATDFLL AHLILFFLSI FILIPYINSV HSLMLFWLRP SKQIRAHIWT
AKQKKERKRA AIGYGILFYS VFLVFVVLVA APLVVGKSLL SGFMPKNLPL
//
