ID A0A367KTR3_RHIST Unreviewed; 2216 AA.
AC A0A367KTR3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Acetyl-coenzyme-A carboxylase {ECO:0000313|EMBL:RCI05537.1};
GN Name=ACC1_2 {ECO:0000313|EMBL:RCI05537.1};
GN ORFNames=CU098_003035 {ECO:0000313|EMBL:RCI05537.1};
OS Rhizopus stolonifer (Rhizopus nigricans).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=4846 {ECO:0000313|EMBL:RCI05537.1, ECO:0000313|Proteomes:UP000253551};
RN [1] {ECO:0000313|EMBL:RCI05537.1, ECO:0000313|Proteomes:UP000253551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSU 92-RS-03 {ECO:0000313|EMBL:RCI05537.1,
RC ECO:0000313|Proteomes:UP000253551};
RX PubMed=29674435; DOI=10.1534/g3.118.200235;
RA Gryganskyi A.P., Golan J., Dolatabadi S., Mondo S., Robb S., Idnurm A.,
RA Muszewska A., Steczkiewicz K., Masonjones S., Liao H.L., Gajdeczka M.T.,
RA Anike F., Vuek A., Anishchenko I.M., Voigt K., de Hoog G.S., Smith M.E.,
RA Heitman J., Vilgalys R., Stajich J.E.;
RT "Phylogenetic and Phylogenomic Definition of Rhizopus Species.";
RL G3 (Bethesda) 8:2007-2018(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001455};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI05537.1}.
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DR EMBL; PJQM01000363; RCI05537.1; -; Genomic_DNA.
DR STRING; 4846.A0A367KTR3; -.
DR EnsemblFungi; RCI05537; RCI05537; CU098_003035.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000253551; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000253551}.
FT DOMAIN 37..545
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 192..386
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 672..746
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1458..1797
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1801..2116
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2216 AA; 248792 MW; 809A05EDF2614A7A CRC64;
MVDHKSLPSH FLGGNSVETA TQSPVKEFVE AHEGHTVISK VLIANNGMAA MKEIRSVRKW
AYETFGNERA IEFTVMATPE DLKANAEYIR MADNYVEVPG GTNNNNYANV ELIVDVAERT
GVHAVWAGWG HASENPRLPE MLAKSKHKCL FIGPPASAMR SLGDKISSTI VAQHAQVPTM
GWSGDNITDV VADASGHVTV PDEAYAKACV KTAEEGLAAA EKIGFPVMIK ASEGGGGKGI
RMVKDSTNFT QLFAQVQGEI PGSPIFIMKL AGNARHLEVQ LLADQYGNAI SLFGRDCSVQ
RRHQKIIEEA PVTIAKPDIF EQMEKAAVRL GKLVGYVSAG TVEYLYSHHD DQFYFLELNP
RLQVEHPTTE MVSGVNLPAA QLQIAMGIPL HRIRDIRVLY GVEHNSASEI DFNFEHPTSL
TSHRRPTPKG HVIACRITAE NPDAGFKPSS GIMQELNFRS STNVWGYFSV VSAGGLHEYA
DSQFGHIFAY GENRQAARKN MVIALKELSI RGDFRTTVEY IIRLLETPDF EENTINTGWL
DMLISKKLTA KRPDTMLAVF CGAATKAHAA ALECFQQYKQ SLEKGQVPSK GTLKTVFTVD
FIYEEVRYNF TVTLSAPGLY TLYLNGSKTQ VGIRDLSDGG LLISIDGKSH TTYSRDEVQA
TRLMIDGKTC LLEKESDPTQ LRSPSPGKLV NLLVENGDHL KAGDAYAEIE VMKMYMPLVA
TEDGHVQFIK QAGATLEAGD IIGILSLDDP SRVKHALPFS GTVPAFGPPH IIGDKPAQRY
NATKHTLEHI LQGYDNQALV QTVVKDFADI LNDPELPYSE LSAVLSVLSG RIPQRLEASI
HKLFDESKAA QREFPAVEFL KLIEDFAREN VTLQSEATAL KNAVAPLVSI FERYRNGLKE
HAYSNYVQLM EQYYDVEIMF SQQRDEEVIL SLRDQNKDNL DKVLEVVLSH AKVNIKNNLI
LMLLEIINPV ATGNALDKYF TPILKRLSEI ESRGTQNVTL KARELLILCQ LPSYEERQAQ
MYQILKSSVT ESVYGGGTEY RTPSYDAFKD LIDTKFNVFD VLPHFFYDAD PYIALAAIEV
YCRRSYHAYK ILDVAYNLEH KPYVVAWKFL LQTAATSIDP NKRIASYSDL TFLLNKTEEE
PVRTGAMTAC NSLEDLEAEL PRILTAFEEE PLPPMLQRNA PPKETRMENI LNIAIRADDT
LDDAAFRTKI SDVIASHADA FRQAHLRRIS VVVCRDNQWP DYYTFREREN YQEDQTIRHI
EPAMAYQLEL ARLSNFDIKP CFIENRQMHV YYAVAKENPS DCRFFIRALV RPGRVKSSMR
TADYLISESD RLLTDILDTL EIVSHEYKNS DCNHLFINFI PTFAIEAEDV EHALKDFVDR
HGKRLWKLRV TGAEIRFNVQ SKRPDAPIIP MRFTVDNVSG FILKVEVYQE VKTEKNGWVL
KSVNKIPGAM HMQPLSTPYP TKEWLQPRRY KAHLMGTTYV YDFPELFRQA VQNQWNQAIK
HDSSLKQPSH LVEAKELVLD EDDVLQKIDR APGTNTVGMV AWLMTIRTPE YPSGRRIIAI
ANDITFKIGS FGVAEDQVFY KASELARSLG IPRVYLSANS GARIGLAEEL IGQFKAAWKN
PADPTAGFNY LYLTPADYDA LVQQGDAKSV LVEEIQDEGE TRLRITDVIG HTDGLGVENL
KGSGLIAGAT SRAYDDIFTI TLVTCRSVGI GAYLVRLGQR TVQNEGQPII LTGAPALNKV
LGREVYTSNL QLGGTQIMYK NGVSHLTAEN DFEGIGKIIQ WLSFVPEVRN GPVTMRMGVD
PVDRDIEYMP PKGPSDPRFF LAGKNDENGK WLSGFFDQDS FIETLSGWAR TVVVGRARLG
GIPMGVVSVE TRTVENIVPA DPANSDSTEQ VFMEAGGVWF PNSAYKTAQA INDFNKGEQL
PLMIFANWRG FSGGQRDMYN EVLKYGAKIV DALSNYKQPV FVYIIPNGEL RGGAWVVVDP
TINKDMMEMY ADTHARGGVL EPEGIVEIKY RKPALLATME RLDETYASLK KQLAEEGKTE
EEKATLKTQL EAREQELLPV YQQISIQFAD LHDRSGRMKA KGVIRKALDW RRARQYFYWR
VRRRLCEEYT FRKITTATNS TMSREQMVTL VKQWFTNDNE SVDFDDADEI VAEWFDKRAS
VIEQRITKIK SDSLKQQVTS LGAVDQEAVI EGFSELLENL SQDARAEILR KLNSRF
//
