ID A0A367KTS8_RHIST Unreviewed; 764 AA.
AC A0A367KTS8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=3-dehydroquinate synthase {ECO:0000256|ARBA:ARBA00013031};
DE EC=4.2.3.4 {ECO:0000256|ARBA:ARBA00013031};
GN Name=ARO1_3 {ECO:0000313|EMBL:RCI05614.1};
GN ORFNames=CU098_011089 {ECO:0000313|EMBL:RCI05614.1};
OS Rhizopus stolonifer (Rhizopus nigricans).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=4846 {ECO:0000313|EMBL:RCI05614.1, ECO:0000313|Proteomes:UP000253551};
RN [1] {ECO:0000313|EMBL:RCI05614.1, ECO:0000313|Proteomes:UP000253551}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LSU 92-RS-03 {ECO:0000313|EMBL:RCI05614.1,
RC ECO:0000313|Proteomes:UP000253551};
RX PubMed=29674435; DOI=10.1534/g3.118.200235;
RA Gryganskyi A.P., Golan J., Dolatabadi S., Mondo S., Robb S., Idnurm A.,
RA Muszewska A., Steczkiewicz K., Masonjones S., Liao H.L., Gajdeczka M.T.,
RA Anike F., Vuek A., Anishchenko I.M., Voigt K., de Hoog G.S., Smith M.E.,
RA Heitman J., Vilgalys R., Stajich J.E.;
RT "Phylogenetic and Phylogenomic Definition of Rhizopus Species.";
RL G3 (Bethesda) 8:2007-2018(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-
CC dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001393};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC 2/7. {ECO:0000256|ARBA:ARBA00004661}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI05614.1}.
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DR EMBL; PJQM01000344; RCI05614.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367KTS8; -.
DR STRING; 4846.A0A367KTS8; -.
DR EnsemblFungi; RCI05614; RCI05614; CU098_011089.
DR Proteomes; UP000253551; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:InterPro.
DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00502; DHQase_I; 1.
DR CDD; cd08195; DHQS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR016037; DHQ_synth_AroB.
DR InterPro; IPR030960; DHQS/DOIS.
DR InterPro; IPR001381; DHquinase_I.
DR NCBIfam; TIGR01357; aroB; 1.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF7; 3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR Pfam; PF01487; DHquinase_I; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000253551}.
FT DOMAIN 78..354
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
SQ SEQUENCE 764 AA; 85290 MW; 4DC2B9296B886213 CRC64;
MVVNTSNITT IPILNVPDTI HVGYNLMDHI ANDITKVISN VSNYIVITDN HLAPLYLQKL
LNTLQSRLSP HQRLLSRVLP FGEQSKSRQA KADIEDFLLD ASCTRDSCFI ALGGGVIGDL
VGYVASTFMR GVPFVQIPTT LLAMVDSSVG GKTAIDTPHG KNLIGTFWQP KRIYLDLAVL
GTLPKRELAN GMAEVIKTAA ISSESEFVKL ETGKNKIEKA IASLDNPNDF SQEKESDREF
LASVVCASAR FKANVVTQDE REGGLRGLLN FGHSIGHAYE AILAPIWLHG ECVSLGLIHE
AELSTSLGHC SYTVVERLKN CLSLYGLPTS FDNECKKKLC FSDVMNAMKV DKKNKGSQKR
IVLLADIGKT VEQKASDVPD TAIEAILAKY VSFKQTTADG CQVGEDKLHA SFQFVATFEH
LKPFIAELSK VLIERFNVKI TTSNETGHTM CVTRMPTASQ YSIHFTDKAG TSSGDSDSYW
FEYVVRSTQQ TLYEDTINYL QKIAGQYQSH IYATSKTQST FVTLPISDYS SILPSILHQW
TEHTDAIEFR VDHLVPLDND WIKTTGMQLM MLRQTTQLPI VYTVRTQPQA GKFDPSLLDL
YLELIQWGHR WGCEYVDVEL TTPSLSQLEA VMKMNQNYPG TRLIASFHDP DHQYPWSGPY
MKSMYGMALS LFERYKHQGV IKLVGFAQTF YDNIELEVFR HHIDPDQDKR IILINMGPNG
KFSRVANYFL SPATHPALPT VAAPGQLSVA ELSLVRKQLA MNLF
//
