ID A0A367KZS1_9HYPO Unreviewed; 986 AA.
AC A0A367KZS1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7 {ECO:0000256|ARBA:ARBA00017647};
DE AltName: Full=ATG12-activating enzyme E1 ATG7 {ECO:0000256|ARBA:ARBA00029897, ECO:0000256|ARBA:ARBA00032823};
DE AltName: Full=Autophagy-related protein 7 {ECO:0000256|ARBA:ARBA00030242};
DE AltName: Full=Ubiquitin-like modifier-activating enzyme atg7 {ECO:0000256|ARBA:ARBA00018730};
GN ORFNames=L249_5736 {ECO:0000313|EMBL:RCI07679.1};
OS Ophiocordyceps polyrhachis-furcata BCC 54312.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1330021 {ECO:0000313|EMBL:RCI07679.1, ECO:0000313|Proteomes:UP000253664};
RN [1] {ECO:0000313|EMBL:RCI07679.1, ECO:0000313|Proteomes:UP000253664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC 54312 {ECO:0000313|EMBL:RCI07679.1,
RC ECO:0000313|Proteomes:UP000253664};
RX PubMed=26511477; DOI=10.1186/s12864-015-2101-4;
RA Wichadakul D., Kobmoo N., Ingsriswang S., Tangphatsornruang S.,
RA Chantasingh D., Luangsa-ard J.J., Eurwilaichitr L.;
RT "Insights from the genome of Ophiocordyceps polyrhachis-furcata to
RT pathogenicity and host specificity in insect fungi.";
RL BMC Genomics 16:881-881(2015).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Preautophagosomal structure
CC {ECO:0000256|ARBA:ARBA00004329}.
CC -!- SIMILARITY: Belongs to the ATG7 family.
CC {ECO:0000256|ARBA:ARBA00010931}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI07679.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LKCN02000024; RCI07679.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367KZS1; -.
DR STRING; 1330021.A0A367KZS1; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000253664; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000407; C:phagophore assembly site; IEA:UniProtKB-SubCell.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd01486; Apg7; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.140.100; Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain; 1.
DR Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR InterPro; IPR006285; Atg7.
DR InterPro; IPR032197; Atg7_N.
DR InterPro; IPR042522; Atg7_N_1.
DR InterPro; IPR042523; Atg7_N_2.
DR InterPro; IPR009580; GPI_biosynthesis_protein_Pig-F.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR NCBIfam; TIGR01381; E1_like_apg7; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR Pfam; PF16420; ATG7_N; 1.
DR Pfam; PF06699; PIG-F; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000253664};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 810..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 924..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..378
FT /note="Ubiquitin-like modifier-activating enzyme Atg7 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16420"
FT DOMAIN 395..625
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT ACT_SITE 597
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606285-1"
SQ SEQUENCE 986 AA; 107672 MW; 97DB2EEDE51F8C3D CRC64;
MLAPTRFIVP SLSPSPARKA TRGSNVHAPA TIICRSDNAN PSHHAHAGPL AAMASPLQFA
TFTSEIELPF YSALFASKID KDKLDESARN VLGLYEPRAE KPENSCRMQI LGNALTSKSS
PLGTARAEGI IKNLNTIEAF KATDKSAMLQ TAARQIWDAI NDGTIYSIPS LLASFVILSY
ADIKKYKFTY WFSFPALHSN PAWRRDGPAQ HFDANESTSL VDAVGTWRYG VDNREHGFFL
VKKIRVLDPD VEDDVAQLLG YTWKVASLRS FEDGFFNGVS ETDCYVAFVD PSTYPEGPGW
PLRNLLVLIR RRFRLRRVNI LCYRDTQAKR HEARSIVLPI AMDAVDDMHT AEMPKVTGWE
RSRNGNLQAQ QANLGEYMDP SRLADSAVDM NLKLMKWRLA PDLDLDRVKN TKCLLIGAGT
LGCYVSRNLM GWGVKKITFV DSGRVSYSNP VRQPLFEFQD CIDGGKPKAT RAAAMLKRIY
PGVESDGHCF SVPMLGHPTT NEAKTKADLS KLQELIQAHD AVFLLMDTRE SRWLPTVMGK
AMGKIVMNAA LGFDSYVVMR HGAEKTEHGQ AELGCYFCND VVAPADSMRD QTLDQQCTVT
RPGVAAIASA FLVEILASLV QHPLGKHAAA PQPTPGFVPD RDPPEHPLGL VPHQIRGHVS
TFQNLVIRGH PYDSCSACSP RVIEAYRRDG WTFLRRALQE TDYVAELSGL AEVQRRAEEK
AADVDWEESD DAVEDTAHCN ATMISSAESI PMASSAAAAA KARSHIDTIT IHDTTPARAV
SMARPGLLLG LLAFRFSALV TDPAGALRSA LPVVAVMQIV YAVVCLPPAG SKATRKARPG
EKKKSSGVGR ITAVLSLVLT AMATPVTFAL MVLFGAPLLD DVAKTMLCSA HLALLGLFPI
FYARGVDSDA LLAIAGATAP LDETFGGLLG AITGAWLGAV PIPLDWDRQW QRWPVTIVVG
MYGGSLLCSW LAGTWFYGMH LSVHAP
//