ID A0A367LGR6_9HYPO Unreviewed; 1426 AA.
AC A0A367LGR6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=L249_5491 {ECO:0000313|EMBL:RCI13626.1};
OS Ophiocordyceps polyrhachis-furcata BCC 54312.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1330021 {ECO:0000313|EMBL:RCI13626.1, ECO:0000313|Proteomes:UP000253664};
RN [1] {ECO:0000313|EMBL:RCI13626.1, ECO:0000313|Proteomes:UP000253664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC 54312 {ECO:0000313|EMBL:RCI13626.1,
RC ECO:0000313|Proteomes:UP000253664};
RX PubMed=26511477; DOI=10.1186/s12864-015-2101-4;
RA Wichadakul D., Kobmoo N., Ingsriswang S., Tangphatsornruang S.,
RA Chantasingh D., Luangsa-ard J.J., Eurwilaichitr L.;
RT "Insights from the genome of Ophiocordyceps polyrhachis-furcata to
RT pathogenicity and host specificity in insect fungi.";
RL BMC Genomics 16:881-881(2015).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI13626.1}.
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DR EMBL; LKCN02000006; RCI13626.1; -; Genomic_DNA.
DR STRING; 1330021.A0A367LGR6; -.
DR Proteomes; UP000253664; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.190.20; 14-3-3 domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036815; 14-3-3_dom_sf.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF48445; 14-3-3 protein; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253664};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..445
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1256..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 157241 MW; E0FBAEF5EECE466D CRC64;
MIWYILYPLR GTTEAPTLPS SHPLYNAFAR YGRYAARHVV ATLLVSAAVA TVLVYPIPFL
FTSDFVNGAS NLPRHVWTVA QPLPYGTAVE PDVIMRSIWV HASYMQALNT ELLVSALNLQ
DDLLGITKNF SPASALHTPS WSKLPDDDLS LTQRDAIHVA NGLTPQSWFF HSPLLYWGCC
RERIMADDDI LSTINNRKNQ STFANVTLRH SIVFSGKRFE ERRLLAADSL VITLLHLQNS
SVGRQWERRA LELPQKVGDQ WNIYPSDGRV ASSQLYEFQF RPISVQDIAS LALAYGLALV
YFLASLSKLR AVKSRVGLIV TVLAQIIFSI MSSFTVCAIF NIDLSRIPRA AYPLVVLAMS
LEHIFRLINA VILTPLEDIV SDRIGQAFAE TAPTAMFSTL QNILILAGLS RLVSPGVSGF
CIFAAIAIVF DFFYLNTFFL AVLSVDVRRM ELGDALAKAS MRHNRNKSDT RGVRRSWWDP
VLQGRIAMST RIAGTIVMFG FVLIAQWHFF SDEGLLGKLE RFYKDLDGEQ TWSQPGSSLL
DSVHQARSPT SWLRIQDHDT AREVINIIKP SSHSYVARVY DPIVFVLKNS DRVPHSKEPT
LLPAAYDFVK HEMARFLVVV VVVIAALRLL TNFLLWEDEE NIGGQHEPDE LPLVSVKSLA
KGHLMDIVLL TASADGHVVS VGLDNTIRVW SLHGVGTSYV IAEGDGPQTT FPVVAVAIDD
DSKWLVLLSR PRNGASSSVT FWNLQSKSWG SSVQADSCRH RPVALLFDPS APGHEPQIMV
IQQDGSMSIL LSSEQTERPL GAIFPPHLIC ARLLAGKGGN DCALARPTIL TVSRQGEVYM
AARYNGDWRS RRLAISGLGE PGAYSIQVVA PLNLFVVTSG DGAHLVDGKD GVVLQTLRTA
KMLPRPLRCA YTRHGSSQLE PTGLASFTLG YVEADSRDVI LQTYMPADDC DAIYLQTPCE
SRNNNWCTWD AARETRKRVV DPGVWDMISD GSAVGIRYVS PAGKAKAVSG LRNRYGKRTA
EPDPLEGWQV WMESRAGCRR EGSESYRLIK DGEQAEHLLV TKVGPKAPVG LNSVAFAFGD
MTKLVIVGTR MQGQGGPATD DIAILFISHH TESGGLSGMA SSEVDQKFLG RLARAVESDN
PLLSSILFKI LGLSLNLAEQ LVAAKKQRRP DPAAPQSFLK RVLHIIWLSR EGLVMLQQYV
IPMVGNYVEL KVLAYKLRAS FHHIFVLFHN QPPVSDMTSW TPELMAAASD MVRMAHDNNN
NNNDDDDYPP LSSVHPTHHP LDGGPVGPPP GFEPHVALLP PSFLLPSKDY LPTAHEYFKE
AAGLADDLLW GSHSLRLSVK TEYAAFLYDC VHDADASRQL AKDTIAEVYD ATEGMDDDMF
RDACELVTVL GKMMTRGLDG SKPSASKPPP LQPPITAPPP GMENAI
//
