ID A0A367LLU7_9HYPO Unreviewed; 4924 AA.
AC A0A367LLU7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=L249_6503 {ECO:0000313|EMBL:RCI15357.1};
OS Ophiocordyceps polyrhachis-furcata BCC 54312.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=1330021 {ECO:0000313|EMBL:RCI15357.1, ECO:0000313|Proteomes:UP000253664};
RN [1] {ECO:0000313|EMBL:RCI15357.1, ECO:0000313|Proteomes:UP000253664}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCC 54312 {ECO:0000313|EMBL:RCI15357.1,
RC ECO:0000313|Proteomes:UP000253664};
RX PubMed=26511477; DOI=10.1186/s12864-015-2101-4;
RA Wichadakul D., Kobmoo N., Ingsriswang S., Tangphatsornruang S.,
RA Chantasingh D., Luangsa-ard J.J., Eurwilaichitr L.;
RT "Insights from the genome of Ophiocordyceps polyrhachis-furcata to
RT pathogenicity and host specificity in insect fungi.";
RL BMC Genomics 16:881-881(2015).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCI15357.1}.
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DR EMBL; LKCN02000003; RCI15357.1; -; Genomic_DNA.
DR STRING; 1330021.A0A367LLU7; -.
DR Proteomes; UP000253664; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000253664}.
FT DOMAIN 4715..4914
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 598..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4077..4596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4077..4093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4103..4137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4161..4184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4185..4236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4237..4251
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4252..4274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4285..4299
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4307..4328
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4329..4360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4361..4381
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4461..4534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4550..4571
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4572..4589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4924 AA; 549213 MW; 26D73AD786FF660B CRC64;
MTSSFDLSRQ TKSLLQDATA LHHLPPDLLD IIRHHSSTSL VDAVAETALS PSLTDRIFAH
FEGVFPDICA RWILNASSDK QKLIVAAAFA RILPFAPCLA EFIRCPHHSS QDRPSSLHLD
LISVDEDFPW NLDSDELLLA LITQWRLLSF DLRLFRPAVS PLFIQSLFRR GSLAVRYVAI
RIYCQLLRAS DKKLETLILE HCGRERAIIA DFDGAPVDFG FLSLHEYRRA QRVIALREHV
ERHDQGPFQE PLLQTLTSYV VPYGNVVLPR PSGSVGEPST LVMTVTTTKN LQDLASMLRE
ADPILLRGPP GAGKTALVHE LAKQLGTYTD MVTLHLNEQT DAKMLIGLYS TNSKPGSFRW
RPGVLTTAIK EGRWVLIEDL DRAPTEVLSI LLPLIERKEL LIPSRGETIR AAQSFRLFAT
IRTAPSMDDR KNMPHLVGIR LWQSLYIEPL ASTELGDVIV QAYPILHKFV AGILAVHQRL
SRLTSSLAFV SRGRSVMDRQ ISLRDLLKWC RRLRECLLSE GSVSGDEPIS ENTRDCMFME
ALDCFVGNCP DAALGEELAF AIAEEMHISR DRAEHYISAN IPVLEDGDHR LGIGRVQLRK
KKQKQKTSGR MQRSKQPFAS TTHAKRLLEQ IAVAVKLQEP ILLVGETGIG KTTVVQQLAE
SLGHKLIAVN LSQQSEAGDL LGGFKPVNVR SLAVPLKEEF EDLFAATGIS ASKNQRYLEQ
IGKSFAKGQW SKVSKLWKEA PRMFIRIVAE IEQMQSETRD DAAQPAKRRK TQSRLQTLIE
MRPRWDAFAR KLEQFDVQVS GESGSFAFSF IEGNIVKAVR NGDWVLLDEI NLASPDTLET
IGDLLTGPDE RPSILLAETG ELEKVVAHPN FRIFGAMNPA TDIGKKDLPV GIRSRFTELY
VRSPDADHKD LLTIVKAYLG SSSTKIDQAA DDITRLYLNT KRMAEEKRLV DGANEVPHFS
LRTLTRVLSY VTSIAPFYGL RRALFEGFSM GFLTLLDKSS ETMLLPLIHH HLLDKHGDPQ
SLLSRTPQHA KDGKQYVRFR NRNRDRQYWL LQGGQTPIER DDYIITPFVE RNLLNLVRAT
STRRFPILIQ GPTSAGKTSM IEYLANFTGN NFVRINNHEH TDLQEYLGTY VSGPDGKLRF
QEGLLVEAMR QGYWIVLDEL NLAPTDVLEA LNRLLDDNRE LLIPETQEVV RPHESFILFA
TQNPPGLYGG RKVLSRAFRN RFLELHFDDI PEDELEYILQ QRCRNTSPPD CRRIVTVYKE
LSRLRQSSRL FESKDSFATL RDLFRWALRD ADTRQAIAVN GFMLLAERVR NEEERLAVKG
VIEKVFKIDI NVDELYSETT APELKRLIGA PNCQDVVWTQ AMRRLYVLVS RALRNNEPVL
LVGETGCGKT TVCQVLAEAV GKQLSIVNAH QNTETGDLIG SQRPIRNRGA ILDALDRDLT
SALGTLGVAI GISTEDKLQA YRSLDENSIA KLPQELVQRV SANETRVKAL FEWSDGALVE
AMREGHFFLL DEISLADDSV LERLNPVLEP KRTLLLAEKG VDNPLVVASD GFQLLATMNP
GGDFGKKELS PALRNRFTEI WVPPLSESRD IYSIVQTKLR DGFKHLTDGM VSFAAWFGQT
FRPMAPTPFS VRELLAWVHF INAFEVADAF MSFVHGASAI FVDSIGASPS ATLMIDPKAI
HQQRLECLKK LGELVECDVS EVYGSKPELV VTDDSLTIGK FSVSRCSNRV TDAGFAFHAP
TTRLNAMRIV RALHTHKPIL IEGNPGVGKT SLVAALAQSC GRPLTRINLS DQTDLMDLFG
TDVPVEGQEA GNFAWRDAPF LQAMQKGEWV LLDEMNLASQ SVLEGLNACL DHRGEVYISE
LDQVFKRHHD FRLFAAQNPH HQGGGRKGLP ASFVNRFVVV YADVLQDEDL KLIASHNFPD
LSPETAGLVI DFIFQLDYKL SVEKSFGLQG GPWEFNLRDV LRWLDLLNSR DPLLRTARVD
DFLQIIVRQR FRTQEDRDEV QKLFGQLAGW KPRTHSLYHD VNSSFSQVGL ALLRRNLDYQ
PERLPGLDTV TVLPELESVM ICVEKNIPCI LSGPSGCGKS ALLTYVAALA GKPIVVFPMN
ADIDTMDLVG GFEQADPLRE LNSTLRNLRD HLRDTVVANA PAELPPEAFR MLYLLDAYSG
DGGDTGDIQS ALKSLEALAE VDPNVGLWVQ KAATLLREPL VLANPKFEWL DGIIVKALQT
GQWLVLDHAN MCNASVLDRL NSLLEPNGFL CINEHCDTDG KPKIIKPHPD FRVFLTMDPS
YGELSRAMRN RAIEVHLPSR SWSRHPCFDK MAEIESGLRR FKNAMDYCET LSSSGLAAYA
CQYACENLSM EDISLLPRFV NGQSWGETQD HQPCFEAMTD LMGFLHSPTG ASNLQAVKNL
YSNIPGAAPL LAVTQPVNAL NNFLVSQLLP RPGEAQWAGL RFEFLRLIHD LQGAVERHCG
EARSSSLPSL TRLQRSAISD RVAVVTKDST VKLCVFLSAA LGAVRTYLAL DFPSLEPWKE
RSRLCCFIAH YLDQTIVLSS RETFDEARFQ AHLALGTSVL QPLITSFDDF RDSEFLGNLL
RLVGSSFKSG FQLSTGLSME RLWHVLRTTP FPDKPAFDQS MGLDRLASRF DAIRWKAQAS
ISNLTQAHDA FEQAYTIVRG GRGSADELVG DLTIAVDSFE LRIGDQAADL QPFFVREFEY
LRQISMLSSG GHRQRETPMG NLAVLSDVPT KSSIMLAITD GPPALLQSVD CLVCQDVHAW
DGKLAVSVWR GLQNLDTVSL RSLSLLESEI PTLGQWVSEL GTEIASDPLM KLNELLWQLL
SEVFGAHEPE LKGFVASART LALQHQVSTP AVTTNGPGHS RSSFDGILEQ IDAQHLRQIS
KDHLLPAVVG LVAAEHDTDR RAHYSALAWM QFSVGLVKLY VPDRVFDPHL RPLVEQEFFE
SLQMQLRERL SALQSLERLS SGLDTSVRME LLEEQLQQVT LPRQDVSPVY RPDVSELDRL
HAECSNVLKV VTGTSMSSLL QQLGAWNYAD DSSKLLQFMK QNVQSLVHRF SSQFAAYQDM
TNTILNALRC LLVGISLSDA AAAEGLQAPT RQLANATPFF DGKGWNASVE KPYRKNFEYL
SLVSATVAVE GITSLPLDSR ESIFECFHSF YDDWCKRLEE DRKAEETRTS LYRFHGSMED
EEEMDLNEFN ELFPTYDGDD SKAKRSASLD HVRNTSLRVA EAHRAIFLER RDPAAAIREA
CMAVGQRIAD EVEEALNIDR RVNAKLLCTL TLHISEKLES LQSTSVDKSG TGKTVNFYTD
PNLFEARKLV LLAEKIKTRF KELQSVDEIG HMQPLADVLE SCDRLLDQVH AEPLAKLIPI
VEQLHAVVYE WQFGGWASKA YAVLPLHDAL TETIIRWRRL ELMTWAKLFD MEEEKCRKDA
YSWWFMAYQV VVAMPLSLVD SPSGLRDYAT SLVRSLEDYL SKSFVGQFKT RIGLLRQLSS
HLRLLSRDYP SLAVIDGAVR NFISYFARFE SAADAVIRDG RAPIDKKMKE VLLLASWKDT
NINALRESAR KSHLKLFRLV RKFRGVLGQD MKAVVGKGLP EETFTSDGVS AGKVTATDAL
DVHVTTLNEV LPAWLDSHRR LANVATTVSV LDRMTQSLDV MDNAAGVVDD FVSGLLASMA
ELKRETPAFM SDESKAQVKH LKTRKRKLLA DTLRDLRMMG VRHNLAQNKL ASQESLAVIL
ATMAPIETWS LSGLAEADYH LHQVLDLAPR ARNAMREHSE DLTGAEISRC VGLVEGLIEI
SLCQRGSIAL ASQRLSSLED MAAEFRRLGG AQKLSRRKHE GDWLSLLPWL AQMLRFATKL
VEAQGKLGLR EVEEVAQKLE RWADRADFHV ASSNDLRKLP GQVSSEAQVQ LEVTVTGDIR
FLREELDELN RNRPDLSFIL QQVSVWTHID DQILDSATTS CMELKTWADS VSTLVDSVLV
AVESTKKTAR AAGEDEAGWL RKHSDDVFAS VQQLHMADVE RGARRCLERM QQIDVDDEAI
STATTSILGL ASPVLDSFLE LCRQCVGRGV DLHRATVHMS AKLTKAFTQV ASQGFCTPQE
KSDETSGDSG QLESGTGLGE GEGAEDISKD IQPDEDLSEL AQEKNEGEQK DMEDEKDAVD
MADQELEGDL GSVDGAQDDE NGSQSGDDGE EDDVEEEAGE VDDLDPTAVD EKMWDGDDEK
AEKDQQGNKP TGRQEDDSVM APEETAEDKE AEQNAKETDV EDEPEAEEDG VTTQDEINRQ
DQNVEDKDTL ELPDDMNLDL EDGLSASSAD DDVDAMSEVD EAKGEEKGGE EEAEEEEGEE
EGCDNDETKD EAMEDRADAK EGEESETEAA DKTGGEDDVQ EEVKSEMDAD EQAEEEGENE
APASADAAKV DKENAAPSDV KSSGQDPTAD QKDADEPAQQ DGQEMGDGAA DQDTSAGKQG
ETTSRSQAEG LEEEKQDDAA DGDKDEAKGS NPFRKLGDAL EKWHRQQAEI RDARPDDVEE
SREQVGKEFE HIKDESEGDT QAMGAARDEE VLPLDESMAI DGDDEDGQRK AMEAEEEEEE
EEEEDEEKGA DDMESRSEQG PDGRAGDDDG WIHQAGGGYR DELQTLEPKQ DDDDDDEQLV
QEASEQLSRT HMAERDLDEC RRQWTELERK TQGLSQSLTS QLRLILRPSR ATKLSGSYRT
GKRLNIKRII PYLASGYKRD KIWMRRSVPT KRQYQILVCV DDSKSMAETS AGSLALEALV
MLSTSLTMLE AGQVGVLGFG SEVITAHELG SSPPLGAEAL QRISFSQERT DIAQLVQKTT
EALRAARRGS CCSSSSAQLW QLAVVLSDGL TPSSAHESIR RLLRTAAEER VMMVFVVIDG
GRGGVVDLKE ARFVRGADGE SSVVVERYLD SFPFPYYLVV REVEELPRAL AGLLRTWFAE
VEDG
//
