ID A0A367XN64_9ASCO Unreviewed; 588 AA.
AC A0A367XN64;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=General amino-acid permease GAP1 {ECO:0000313|EMBL:RCK55085.1};
GN Name=GAP1_9 {ECO:0000313|EMBL:RCK55085.1};
GN Synonyms=GAP1_8 {ECO:0000313|EMBL:RCK54474.1};
GN ORFNames=Cantr_04809 {ECO:0000313|EMBL:RCK54474.1}, Cantr_04814
GN {ECO:0000313|EMBL:RCK55085.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK55085.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK55085.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK55085.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. YAT (TC 2.A.3.10) family. {ECO:0000256|ARBA:ARBA00006983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK55085.1}.
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DR EMBL; QLNQ01000030; RCK54474.1; -; Genomic_DNA.
DR EMBL; QLNQ01000030; RCK55085.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367XN64; -.
DR STRING; 5486.A0A367XN64; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004762; Amino_acid_permease_fungi.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR NCBIfam; TIGR00913; 2A0310; 1.
DR PANTHER; PTHR43341; AMINO ACID PERMEASE; 1.
DR PANTHER; PTHR43341:SF1; GENERAL AMINO-ACID PERMEASE GAP1; 1.
DR Pfam; PF00324; AA_permease; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..541
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 63901 MW; 28CEAD70CA3584DE CRC64;
MPEKELDYIR SKDAAGSTDK DGGVYIDAFD KQDAAPPKKG FAKFVDGFRR ADAEELGIDP
NLSEAEKIAI MTANSPLSRS LKNRHLQMIA IGGSIGTGLF VGLGLALSTG GPAGLIIAYG
LIGTMIFCTV MSLGELAVTF PVSGAFVTYN SRFIDPSWGF AMAWNYAMQW LVVLPLELVA
ASITIKYWDS HTNPAAYVVI FYVFIVFINF FGVRGYGEAE FIFSAIKVIA VLGFIILGIV
LCAGGGPQGG YIGGKNWHIP GAPFPNGAKG VMTVFVNAAF AFAGTELCGL AAAETANPRK
ALPKACKQVF WRITLFYIIC LTLIGLLVPY NDERLFSSSS VDASASPFVI AIRNAGISGL
PSVMNVVIMV AVLSVGNSSV FGSSRTLAAL AASNQAPKIF GYIDKQGRPL VGIIFQLLIG
LLCFLAASPK EGDVFNWLLA LSGLSSIFTW GSINLCLIRF RRALYVQGRD TSELAFTSVV
GFWGAAWGLL LNMVVLCLQF WVAVWPLGES PSAEAFFSAY LSVPFVLACY IGHKLWTRNW
KFYIRASKID IDTGRRELDL DLVKQEVAEE KAYYASLPIY RRVWHMWC
//
