ID A0A367XVG6_9ASCO Unreviewed; 858 AA.
AC A0A367XVG6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Calcium permeable stress-gated cation channel 1 {ECO:0000313|EMBL:RCK57584.1};
GN Name=CSC1_2 {ECO:0000313|EMBL:RCK57584.1};
GN ORFNames=Cantr_06441 {ECO:0000313|EMBL:RCK57584.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK57584.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK57584.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK57584.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK57584.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QLNQ01000028; RCK57584.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367XVG6; -.
DR STRING; 5486.A0A367XVG6; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..213
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 234..463
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 474..739
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 858 AA; 98490 MW; BC814646EE21E428 CRC64;
MIESMIRSLK NMDVQSYGSA YADDDMIYRP PSGRVARYQV IIASTLGLIA VLLFSLLRLK
YPKIYVANFN DLNFSFHSTS RRNLPRLPSK SLFGWIPTVY RISESQILEY AGLDAVVFLE
FFKMCIKVLT ICLVFALVVI SPIRYKFTGR VDHDYPDDDD NTNGTAIVRK VLRETTRVAK
GGDDSGPAYQ QFLWLYTIFT YVFTFVVVYF LFKTTNKIIN MRQKYLGSQN SITDRTVKIS
GIPGLLRDEV ALTRHIDNLN IGEVDSILIV REWQNLNKLF KIRRKILRRL EESWVEYFEK
NGLVDKLDLL ALHPQVGELY NIENRYTDDE IENNYSDWAT QANNITGSAN TDEGSDSIAA
SSVDSLNRLL NDELNTRPSF KKGWFGLFGP RVDAITYYSE KLEVIDKEIK RARTREYPAT
SNAFLTMKNV SQAQMLAQAV LDPKVNHLIT SLAPAPHDIR WDNMSLTRQD RNTRIFMVTL
FIGLMSVLLV YPVRYLASLL NTKSISKLWP SLGRAIKDHN WAKTLITGFL PTYLFTILNI
VIPFFYVWIS RRQGFLSHSD EELSSVSKNF FYIFVNLFLV FTTFGTASLV DTTRIASDLA
RSLRDLSLFY VDFIILQGLG IFPFKLLLLG NLLRFSTHSV FRCKTPRDYL KLYKPPVFNF
GLQLPQPMLI FIITLVYSVM SSKILTAGLL YFIIGYFVSK YQLLYACVHP PHSTGKVWPL
IFSRIILGLF LFQITMVGAL ALQNAITCAS FLAPLPLLTL YFWWSFQKQY IPLSMFIALR
AIENNEGTAQ SGDVEQNANM ANKTLDERRE LNTKYEYPNL VDDLDGPMIA LEGNDMLLVN
QDGTTVRKRQ TFNSEWDY
//
