ID A0A367Y024_9ASCO Unreviewed; 4929 AA.
AC A0A367Y024;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN Name=MDN1 {ECO:0000313|EMBL:RCK59213.1};
GN ORFNames=Cantr_07077 {ECO:0000313|EMBL:RCK59213.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK59213.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK59213.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK59213.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK59213.1}.
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DR EMBL; QLNQ01000027; RCK59213.1; -; Genomic_DNA.
DR STRING; 5486.A0A367Y024; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472}.
FT DOMAIN 4721..4918
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4062..4593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4062..4077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4089..4103
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4112..4168
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4169..4197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4200..4215
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4226..4244
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4258..4366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4405..4425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4444..4514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4536..4552
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4564..4581
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4929 AA; 558530 MW; 1A1EEAB42F901484 CRC64;
MDNHITVSLD QVEDLYSTYR SHYPLKKSLP KELFKFNKNL TIDENINQLA LHAIDHTLPI
YYCYKPIFLE IIARWINHTA EFENEYKKSH TKRTNNIPGS IVLLALSRLL QISHEYLNLF
ELFLAKNEFW AHIDTVSTLE LESILLAFFR LLKYDTDRFK PFVQPKQLYQ IINKHGDKYG
VSKFLAIQII SLYLQAAEVS KNRMIETHLQ DTDLTSTYED DKIDYSFIAL IEAKRISNFL
SLPKNEFLPT TTKNCITITP DLLSPIVTSI CGILVPHLLS SSTNQPQLQE TKFVPTNSAV
EVLRKLASSI QYNKPVMLYG KAGAGKTFLI NQLASYMSYS DSIVKIHLGE QTDAKLLLGT
YASGEKPGTF EWRTGVLTSA VQEGKWVLIE DIDKAPTEVL SVLLTLLEKR ELSIPSRGEV
IKAKNGFQLF STIRTSNDSK KDAIPDLIGI RLWELIKVEV PNELDLRNIL VTKFPLLVNL
IGAFIKCYNE IIRIYSLSSF VSLNKGSHPR VISFRDLMKF CSRCNNMLSL EGITEPDQLV
ESSVFDNIFA EAVDCFGSAI TEPQALAPLI NAIGEALEIP TSRINLFLSK HVPMFINDEE
KLKIGRATLK KSNKDKALYN KRQSSNSSSF ARTNHSLRLM EQIGVAIEMV EPVLLVGETG
TGKTTVVQQV AKLMNKKLTV INVSQQTETG DLLGGYKPVN TKTVAVPIQE MFENLFIGTF
SEKKNAKFSK ILTKCFNKSQ WKNVIKLWTE ALKMAKDLLS EPESEGEDGD GAPRKKRKLQ
SFEKSVLLEK WLEFETKIKE FELQATTLDN SFVFNFVEGS LVKAVRNGEW LLLDELNLAT
SDTLESIADL LADTINQRSI LLSERGDVES IKAHPEFRIF GCMNPSTDVG KRDLPLSIRS
RFTEIYVHSP DRDIQDLLAI IDKYIGRFAV GDEWVGNDIA ELYLKAKELS ETNKIVDGAN
QKPHFSIRTL TRTLTYVCDI VSIYGLRRSL YEGFSMAFLT LLDAKSEDIL KPEITKYTIG
RLKNAKSVMT QTPPAPTSNP DDYVQFKHYW MKHGPGEVVP QPHYIITPFV EKNMLNLVRA
TAGRRFPVLI QGPTSAGKTS MINYLANITG HKFVRINNHE HTDLQEYLGT YISDSTGKLV
FKEGILVEAL RKGHWIVLDE LNLAPTDVLE ALNRLLDDNR ELFIPETQEV VHPHPDFMLF
ATQNPPGLYG GRKVLSRAFR NRFLELHFDD IPQDELEIIL KERCQIAPSY GKKIVEVYRQ
LSIQRQSTRL FEEKNSFATL RDLFRWAMRD AVGYEELAAN GYMLLAERVR KEDEKEVVKK
TIEKVMKVKL DMDAYYRSLE IEEIFNSDSS IVWTKAMRRL AVLVFTSIKY KEPLLLVGET
GCGKTTVCQI IAKFLGKELV TVNAHQNTET GDLLGAQRPV RNKFETQSRL FNHLIELFGK
LDIKVGDDLT LDHLLAKYKS LAIPDELKEL SDAIEEEKKN MTLLFEWSDG PLVRAMKLGD
FFLLDEISLA DDSVLERLNS VLEPERSLLL AEKGTEDAFI TAQESFEFLA TMNPGGDYGK
KELSPALRNR FTEIWVPSME DFNDVHQIVE SRIVHKELTS SIVKFSEWYA KQFGGGHTNN
GVISLRDILA WVEFVNSCDN ATTSALAGLY HGASMVFIDA LGTNNTAYLA ENETRLQAIK
KECVDRLSSF ANHDLSEFSS TKFQVSVNSQ NLTAGLFSIP VIEGSEHNKS FNLDAPTTAA
NAMRVIRAMQ VKKPILLEGS PGVGKTSLIT ALASATGNPL VRINLSEQTD LVDLFGSDAP
AEGGKAGEFV WRDAPFLRAM QRGEWVLLDE MNLASQSVLE GLNACLDHRG EAYIPELDKS
FKRHPKFTVF AAQNPQYQGG GRKGLPKSFV NRFTVVYVDT LKSDDLNMIS QHLFPTVDAN
DCSKLIQFMS KLEEEVVTKR LWGSQGSPWE FNLRDSLRWL SLYTSGNIAQ DIELSDFIQM
IICQRFRNPD DRVRARELFE SSFGTIKSRD NYFNISESFV QAGGSLVARN DLIQYVNGSN
NLLSLQCNFE FMETAFRCVT HNIPLILTGP TNSGKTDLVR YLATSLGAKL DEFSMNSDVD
SMDILGGYEQ VDLSRETNAL LDRTFKLINK LVVTNLRYQE SDSEILSKAL ELLAFVENNH
HDQKSFDNFR NILAEFAAYH AIPEIKDLVA ASNQLVKKIN EEKSVKFEWF DGLLVQAVEK
GNWLVLDNAN LCSPSVLDRL NSLLETNGSL IINECSLQDG QPRILKPHPN FRLFLTMDPK
YGELSRAMRN RGIEVYMDSL DKRMTSFDSD VLGIKKEKDL GLSDQIEDLV IEDKRIVPTF
TFNFDKDSLI RSFSLVEDAF ASGELSLSAL WSFVPLANFG IIAKWKEAVD ASSEFGPLSK
EYASDAYSSL SAFKEASLPE QLEEIYRGPA KRANEITEKS VHFDKCQSFH TLANVYIVAS
LLEKHPEIQT AESTMIFETL GSVIKLNTMV SNIEQMAMDK KVHDLSFIEK SAAAQLGRDI
KSRPRLEIYS FVKLLVSFVT KTFYESTKST LFSDFVYKPL HELCLLVLGA IETAEGKNES
KLRVYQELIT KWAYKYLATN QELLSQFETA TSSFSQQLQL ATGLAMNEIW ESCRGQYPQT
FEAWEDLQRL FNLMEEFDKL SKVQFPESAE VVSSFGKLIG DLYNSIVSGE YDRDELSKIF
GKLEQGIAEL SSVSESFNTS RANMFIEDFT NISNFIELSG GNQGLMKLYN FSERSMMSLV
KEESFKPYPG IFDSLWIDDK SRISPLFTGE LIVSVLGKTL GFNNTSGKLL DQANFDLKLV
SKSLIEYSPD ILKDEKKVFA ELLSSWSSMI LQTLGIDSSS EPAAIVFDIT MKYGPESPLM
TVFSEFLLPA LTIAKTSSDL KSLGRAWVLF SCGLIQLYVP SSPYDPAIKE YVLYKVFEDQ
QKFSTDLIAS WKSARRVNNG DDQTFLESTL KSLTELEAPS NPRVYRDGKS VDGLFEEWDS
IMESNIAVEP IEKLLKAALS LSDKSENQVK MFQNNTSQFV MRLSKNYMLY SDLNDILRGY
IYGLKLGFEL ISIDSKQGKY AYPEDWSLDV SNFTDLKSIE ETFPFAKEFS KSVKIDSPVP
EFMMSYFMKL GFAHRSETAE ANGILIQALQ QLYYRWSLRR IKEEKETIQQ GSLYKYNDPD
EDIEGDFKKL FPDFEDVLDV DTAGAKKNNQ SFESIYESIA TAYIKEYLLG EKDSLTDLTH
EGGELVVQLG KYGNELRQSS NNSSSLTTLV NELATTHTKF NQSTSEFNFY QDANPSEVKR
AVSIMTTVYN LSKKLLDQWP EHATLKNIVF AANEFLSYPI GLPLGRYLQK LEQIYTFIAE
WQKYASSQVS LKDQFDVLTN LIVSWRKLEL STWKSLFKFE ELSVEKNIGK WWFHLFEVII
IPLLNGEEET EGRDSAVKVL SALNVFMSKV TYGEFKGRLS LLKAFKNHAQ EIDKSHPIVD
SLANFVTFYE QFQSTIEANI QDSKKKLEKD ISEVILLASW KDVNIDALKQ SARRSHNNLY
KIVRKYRSLL STQVQPIIEQ GITESTGGIK QFKDLPGIQT VVSSNERNLV RAISTWSERP
RRLQDLTLIE NNMNVYIERV SKEELPSLLE FASELVSEMD RLKKETPSEL KESNKKLVGA
LKSQKRKLLS DTIKEVRRSG LKTSLTSNIL ATQKSINLIL SNSVSFDSSL VENSDAYFFR
VLDLLPRLRA SVSEGTEDVP QVDIEKGLSA VENLIHSLIV TRVPIKKFAD SLESLSGLYE
SVYNLANLNN LSLVATPAST HDSIKLNIGT IKHVQFWLPK LLDYATVTLE SAKKFGIDVQ
LQLFYQLKIK LNELNLKIDE NVFSNDTAKY VEKFGGFYSS MIASLEKWQV DNPQVSFVAD
VVLQWISNNS AIGEITNSTT LESLESVESV EQEFRSLTNS IILVVQKVIE CQKEEISRDD
DNWLITSQHR ISDYVKNLRL KTIISKLSKC VTMAASIEYN SHASQLISSL VSFTYPIVNQ
FMKLSLQVFE KSRSNYYDLS KATFILSNSL YTLSTKGFCT PEKPNDSKDD DNNLHDGTGL
GDGEGAQNNS NDVEDDEDLS EQAQQPNEEN KEKDENEDEN DDAVDIEGDM AGNLEEASDQ
DNDDEDDKEE EGDEELDEEV DDIDDLDPNA IDEKMWDEEV KEDKKEKDSD KMPENSNNDD
NMEAMEDEEE DNANPQESKE NDNDQQGDDD KEDDEADEEK DVGEQEDEIK NQENEQLEEN
VPETETLDLP EDMNLDDDEE MKDEEDGDDD KFDDKLDDEV NVEEEKSNDD DGKAQEEEED
QEMEGDENAD DRDEQDNEEE QEAEGEEEAQ GENEVNEDVM DSEDETVGED NNTKQEEEGG
NDNESDQEQT AEGVEGANDI DTEDVDMDSA VKQESGEKGE GADNQVVEEN EDIGAAGTAS
AEQEQQEKQE KQEDSVQDDA REKANESLKQ LGDSLKEFHR RRQEILESKQ AEEDEKVDES
AKERPDEFQH VDGENADFDT QALGAADKDQ VQSIDEDKAI DDDEDQGPEE SQDEIKQEEK
PADEDMKDVE DDEVADVNEE NPDADFEGKS KSAFIGERKV TEMEDDTMTA KEIEEDEEKD
DVEMEEIGNT DLDEINDSPA MTLEEARNLW KVSELATQEL ASGLCEQLRL ILEPTLATKL
RGDYKTGKRL NMKRIIPYIA SDFKKDKIWL RRTKPSKRQY QIMIAVDDSK SMSESKSTEL
AFHSIALVSK ALSQLESGGL SIVRFGEDVK VVHPFDKPFN SQETGAKVFQ WFDFQQTKTD
MKQLCNQSLQ IFEDAKATSQ SDLWQLQIIL SDGVCEDHET ILRMVRKARE EKIMMVFVVI
DGINNKESIM DMQQVSYVAD ANTGAMNLKV DKYLDSFPFE FYVVVKDINE LPEMLALILR
QYFSEVSSV
//