ID   A0A367Y502_9ASCO        Unreviewed;      1130 AA.
AC   A0A367Y502;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   22-FEB-2023, entry version 9.
DE   SubName: Full=Target of rapamycin complex 2 subunit ste20 {ECO:0000313|EMBL:RCK60944.1};
GN   Name=ste20_0 {ECO:0000313|EMBL:RCK60944.1};
GN   ORFNames=Cantr_07990 {ECO:0000313|EMBL:RCK60944.1};
OS   Candida viswanathii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK60944.1, ECO:0000313|Proteomes:UP000253472};
RN   [1] {ECO:0000313|EMBL:RCK60944.1, ECO:0000313|Proteomes:UP000253472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK60944.1,
RC   ECO:0000313|Proteomes:UP000253472};
RA   Ahn J.;
RT   "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT   Korea University).";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCK60944.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QLNQ01000026; RCK60944.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A367Y502; -.
DR   STRING; 5486.A0A367Y502; -.
DR   Proteomes; UP000253472; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        85..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          38..429
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          482..712
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          896..975
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
SQ   SEQUENCE   1130 AA;  131249 MW;  E6601D6786AA2A0C CRC64;
     MSLLLPEKHN NTESPTWVLS DLLSSISSLK DKNEYSIVAK ANDLVLLFQQ HPDLTKDVQI
     KTVLPRIQFM LYHPVSEVRS SCYRIIRYLI VNYESLMILV QLKLLIYIII SLSRTRKATL
     VEMEQSLKLV REFLTVEKGA DLISVGLIKT LITIIEENGE SDEKYGEKTV DVIPEIFKNC
     CLETICEISL MKPELVCHSG GFKVLINAML EKLIEISSSC VMIILKLLDY ENSRKFVRNG
     YDLDSLISIY SNLCDNEDDS PGTTTTTTKI RKFSSMKLQK VSFLISMLLR NFNGIMAYSI
     NDFTSIKNLL MNLRKKNTKA RESILDLLLD ALRIRIFPWL KNSPIGDSIV RYNEVLGHGE
     SFDFEFQEVQ DEFSRNILHH HQGLLTLILV KNGIFQHLSA IIEEKDDTCS TKATVLLTNL
     YKLASSYLPS EMVNENLLPD LSLHASYEVV HETRHKFTAT TEYNQHIKSS LKQINIQSKY
     NVDDNEFKTM VTNSKILAIK EFEDWNWSIL LNLIQGPLTN PKRFDEILEK APKFFKRLLS
     FYRPFKYRFS TITNANKNCL RYINFGCQLI EMFLNLENGI KYLGGSKLLP QLSEVVAQID
     PYSGISSKDP ILSKKRLEST ASTGYIRFIG VLSGHSAGIK MLEQWQFFTL FLNIISSTGE
     SDVNNLFVLT LFKYTDFSID SQFRNLLKMT FKVSNLKVKN YLLKHLLPQL IKVQECEAFI
     VKLLVENLYD TDDIVSRSVD LLYSFFNDHN FLNLQLLIKF KPRVEILEKY PLGKKLLMKF
     LQFPMGFIYL ESLGFLDLKF DEWTKLQDFK YLHAIEAMLN YQFLPYIRTP VVADDQLYFL
     QNLLSTEEGL NFFQYGRGKD FLEVIMSSTE FMFHQILHDD DFYDIDNQDE GRNFVVNSLK
     QNLWIIGGIA LGQYGIQLLD PMYNINLTNP IISDIIYNFQ SCPIWQIRGI CFYVLGMISS
     TIEGMEILDE FNWVSCMDQY GNSKKLAYPR FDRLVDVFNV EMTNPYRDTR YYHIFNSIPM
     EITTENDEVA VVVDSDEELI DDLTISLRHK IIVLITNLQA VLTKIENKAI RELNKIRFRY
     SEIFENDVEL FLEIMKLIDK GNFSFYQRSY IFNLFLSGNS KILELILKKR
//