ID A0A367YBC6_9ASCO Unreviewed; 722 AA.
AC A0A367YBC6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 08-NOV-2023, entry version 17.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=KU70_0 {ECO:0000313|EMBL:RCK63165.1};
GN ORFNames=Cantr_09820 {ECO:0000313|EMBL:RCK63165.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK63165.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK63165.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK63165.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK63165.1}.
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DR EMBL; QLNQ01000024; RCK63165.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367YBC6; -.
DR STRING; 5486.A0A367YBC6; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF2; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR PIRSF; PIRSF003033; Ku70; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RCK63165.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 351..544
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
SQ SEQUENCE 722 AA; 83740 MW; 5EA4BB62E9D9E366 CRC64;
MSWNTQDASQ DPSNTFQQYE IREGIAFLIE ITPELLAPLS ELNSNSQLYE ILSSINDLMQ
ELIMTSRGTG IGIYFYNCDA STTLRSMKSP RNFQRLFHLN VLNLLNMKKL SDLIQDVNVR
SLHEIFKYKP SQSETQLTTV LSKMIDEFTN KKEFNKRRMF WITTNDKPYT EESTKEAIWR
IIDDFYYYGF FIEPFFLSAG DKKFDFELFK DIFMNTNYLK RSQERALQEE EQERDLDVQQ
DIVRPWGFSK DSPIFKYSIV GEQIRQRIFR IKEVRRMQFT CDLILSDDGT VGGGLGCTIK
AYTLYSHEQI KKNDLLLYTR DETLKKVFHE STLRQNGERI DVKNDKEKSV AQLREEAGIR
KGYEIGGGED IVFLNREQLE FLTNYTFDHR LEETDSFDKT FIDVTVDESE QGKPVVFSRA
PYLKLIGFRD LLHFSPVYSC GAPTFITADT NNGMSSSSLK GGFTNSLDTF ASLYRSCIKL
KQYAVVFGCT RASSRPFLYA LYPTVTTNSS KLIAGTEFPQ GFLLIKLPWL EDVRALPADY
IEMSKSETVQ TDDELVGGFK ELLPKFELQA YDPRDFPNPS MNYFYKVAKH EILQIDFHPD
EKLLLKNDIT MKRLAEIKRL INNDDSSIEL LKKINLKLNE IQRTSAKKRP AIIVDPPKKK
PKASVEVSDN EILVAWKNDT LVQFSMDQLR SFRKKFPDVK AASKKADLIE NIKEFLDSRQ
KQ
//
