ID A0A367YFE8_9ASCO Unreviewed; 861 AA.
AC A0A367YFE8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Calcium permeable stress-gated cation channel 1 {ECO:0000313|EMBL:RCK64339.1};
GN Name=CSC1_0 {ECO:0000313|EMBL:RCK64339.1};
GN ORFNames=Cantr_00052 {ECO:0000313|EMBL:RCK64339.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK64339.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK64339.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK64339.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK64339.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QLNQ01000022; RCK64339.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367YFE8; -.
DR STRING; 5486.A0A367YFE8; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..216
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 237..466
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 477..742
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 861 AA; 98896 MW; 1FA62B2640F51488 CRC64;
MIESMIRSLK NMDVQSYGSA YADDDMIYRP PSGRVARYQV IIASTLGLIA VLLFSLLRLK
YPKIYVANFN DLNFSFHSTS RRNLPRLPSK SLFGWIPTVY RISESQILEY AGLDAVVFLE
FFKMCIKVLT ICLVFALVVI SPIRYKFTGR VDHDYPDDDD DDDNTNGTAI VRRVVRETTR
ITKGGGDSGP TYQQFLWLYT IFTYVFTFVV AYFLFKTTNK IINMRQKYLG SQNSITDRTV
KISGIPGLLR DEVALTRHID NLNIGEVDSI LIVREWQNLN KLFKIRRKIL RRLEESWVEY
FEKNGLVDKL DLLALHPQVG ELYNIQNRYT DDEPENNYSD WATQTNNLTG SANTDEGSDS
IAASSVDSLN RLLNDELNTR PSFRKGWFGL FGPRVDAITY YSEKLEVIDK EIKRARTREY
PATSNAFLTM KNVSQAQMLA QAVLDPKVNH LITSLAPAPH DIRWDNMSLT RQDRNTRIFM
VTLFIGLMSV LLVYPVRYLA SLLNTKSISK LWPSLGRAIK DHKWAKTLIT GFLPTYIFTI
LNIVIPFFYV WISRRQGFLS HSDEELSSVS KNFFYIFVNL FLVFTTFGTA SLVDTTRIAS
DLARSLRDLS LFYVDFIILQ GLGIFPFKLL LLGNLLRFST HSVFRCKTPR DYLKLYKPPV
FNFGLQLPQP MLIFIITLVY SVMSSKILTA GLLYFIIGYF VSKYQLLYAC VHPPHSTGKV
WPLIFSRIIL GLFLFQITMV GALALQNAIT CASFLAPLPL LTLYFWWSFQ TQYIPLSMFI
ALRAIENNEG TTQSGDVEQN ADMANKTLDE RRELNTKYEY PNLVDDLDGP MIALEGNDML
LVNQDGTTVR KRQTFNSEWD Y
//
