ID A0A367YFK1_9ASCO Unreviewed; 434 AA.
AC A0A367YFK1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=tRNA (Guanine(10)-N2)-methyltransferase {ECO:0000313|EMBL:RCK64389.1};
GN Name=TRM11_0 {ECO:0000313|EMBL:RCK64389.1};
GN ORFNames=Cantr_00014 {ECO:0000313|EMBL:RCK64389.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK64389.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK64389.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK64389.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK64389.1}.
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DR EMBL; QLNQ01000022; RCK64389.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367YFK1; -.
DR STRING; 5486.A0A367YFK1; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:RCK64389.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RCK64389.1};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 180..293
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 434 AA; 49780 MW; EFF5DD4DD6B3845C CRC64;
MKDYIVHFAL TFPEFRIAEL QELASFYGFP VDLSGHDENS PFLVVSLEDD EQACQLVARS
VMSYGIYELW GYGKTYEELH ADVKEKSSDK FDKYKNASFK FDFKTFQGKQ SNRNKVKTIE
SFGYLEFEGK IDLQNPEEVF VVMEEYIKGG PKTPAHIWFA RELQLSERSG GVIEKYDLKK
RNYIGTTSFE AELSLVTCNL AQVAPGKIVY DPFTGTGSFL VAAANFGGLV MGSDIDVRML
NGKGADSNVK SNFKQYGTKE NFLDVMTMDF THNTLRSDFQ IDTIVCDPPY GVREGLRVLG
AKNEEKAAGR ENDIFNGEIA YLRREFIPPK KPYQLASLLE DLLQFASERL PIGGRLEFWM
PTANDNFEEH IIPQHERLEL LHCLEQLFNM WSRRLLVYVK RDATYQGVTS NGLKEKNIKD
FRIRYFQKFS TNGK
//
