ID   A0A367YFR1_9ASCO        Unreviewed;       966 AA.
AC   A0A367YFR1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN   Name=RPN2_1 {ECO:0000313|EMBL:RCK63871.1};
GN   ORFNames=Cantr_10564 {ECO:0000313|EMBL:RCK63871.1};
OS   Candida viswanathii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK63871.1, ECO:0000313|Proteomes:UP000253472};
RN   [1] {ECO:0000313|EMBL:RCK63871.1, ECO:0000313|Proteomes:UP000253472}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK63871.1,
RC   ECO:0000313|Proteomes:UP000253472};
RA   Ahn J.;
RT   "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT   Korea University).";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000256|PIRNR:PIRNR015947}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC       {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCK63871.1}.
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DR   EMBL; QLNQ01000023; RCK63871.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A367YFR1; -.
DR   STRING; 5486.A0A367YFR1; -.
DR   Proteomes; UP000253472; Unassembled WGS sequence.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR016642; 26S_Psome_Rpn2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR   InterPro; IPR048570; PSMD1_RPN2_N.
DR   InterPro; IPR040623; RPN2_C.
DR   PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   Pfam; PF01851; PC_rep; 4.
DR   Pfam; PF18004; RPN2_C; 1.
DR   Pfam; PF21505; RPN2_N; 1.
DR   PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253472};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          5..311
FT                   /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21505"
FT   DOMAIN          759..938
FT                   /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18004"
FT   REGION          813..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..876
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   966 AA;  106031 MW;  8A71CB62548F6679 CRC64;
     MALVSAAPYL ALLGEPDSSL KTYALSSLNQ VVDQLWAEIA NNITELEELY DDDSFEKKEL
     AALVISKVYY NLGDFEASVK YALLAGDEFN LEEQSQYMET IVSQCINLYN SLSQKKFSDG
     SVKVDPRLTS IFEKMLKKCL NANEIKLTLG IALESYRLDL VESILKEQIS VNEEQALSLI
     NYVLVCSNST VKNYDFRVQV LNSLISLLLS LKKHQDFFTI IKIIVQLNDF ELAVKLFQEL
     INQKEDLIAY QAAFDLVNAA SQELLDLVIK KLSTSEVEVD EARQVTTKKI LNILSGVPTC
     DLDNTFLFKN NNADVTILNK TKNLLDGRSS IFHSAVTFAN AFMHAGTTDD SFIRDNLEWL
     GRATNWSKFS ATAALGVIHK GNLSQGRTIL KPYLPGSSGS ANTKGGSLFA LGLIFAGHGR
     EVIGTLKSFI DENGNAAGSN DIDIQLHGAA LGAGVAGMGS RSEELYESLK VVLYSDSAIS
     SQAAAFGMGL VMLGSGNEEA VHDMLTYALE TQHENIIRGL AIGIALLNYG CEERANETID
     NLMSQESSIL RYGGAFTIAL AYAGTSNNHA IKKLLHFAVS DPSDDVRRAA VMGLGFLLIR
     NYTAAPQIVK LLSQSHNPHV RYGTALALGI SCAGRAYPAA IEVLEPLTKD AVDFVRQGAL
     MASSMILIQQ NEFIYPKVKD FTKQYADTIK NKHEDALAKF GATLAQGIID AGGRNLTINL
     ENSQTNTLNT KAIVGLTLFV QSWYWFPLAH FLSLSFAPTS IIGVRGSDLK APKFKLNCHA
     NPEYFQYPPK TEETKEKQPD KLATAVLSTT AKAKTRAKKK QSQKEDAAAA AAGTSTGEAA
     KTEDKMDVDE ESKPKVEGEK ATTQEETKKE KPVSDEPAVV RYTKTAYEIE NLSRVLPLQS
     NFISFIKDDR FVPVRKYRGS SGIIVLQDNK PDEKIEFIKT VRQLNITEAP VPEPFTLSGD
     DLKDDE
//