ID A0A367YHA8_9ASCO Unreviewed; 734 AA.
AC A0A367YHA8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN Name=GCD6 {ECO:0000313|EMBL:RCK64969.1};
GN ORFNames=Cantr_00721 {ECO:0000313|EMBL:RCK64969.1};
OS Candida viswanathii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5486 {ECO:0000313|EMBL:RCK64969.1, ECO:0000313|Proteomes:UP000253472};
RN [1] {ECO:0000313|EMBL:RCK64969.1, ECO:0000313|Proteomes:UP000253472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20962 {ECO:0000313|EMBL:RCK64969.1,
RC ECO:0000313|Proteomes:UP000253472};
RA Ahn J.;
RT "Whole genome sequencing of Candida tropicalis (genome annotated by CSBL at
RT Korea University).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCK64969.1}.
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DR EMBL; QLNQ01000021; RCK64969.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A367YHA8; -.
DR STRING; 5486.A0A367YHA8; -.
DR Proteomes; UP000253472; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000313|EMBL:RCK64969.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000253472}.
FT DOMAIN 562..729
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 446..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 82565 MW; C5BC0BF147EA968E CRC64;
MAPKSKRQAA VPSKSRKLKE IVDERFQAIV LTDSFETRFM PLTAVHPRCL LSLANVPLIE
YTLEFLATSG VNEVFLMCSA HADQVQEYIE NSKWVSSHSP FTVTTVMSIE SRSVGDAMRD
LDNRGLITGD FLLVSGDVVT NIDFSKVMQF HKQKKAQDKD HILTMVLNQA SPLHRTRSQL
DPATFVLDKE TNRCFYYQRI PPVDGKKTSI SMDPELLEDI TGDIMIRNDL IDCYVDICSP
HVPQIFQENF DYQYLRSDFV KGVLTSDLLK KTIYAYISKE SSEYAARVES WGTYDAISQD
ILARWCYPLV LDSNLVEDSS YCYELNNIYK EDKIVLAQSC KIGNSTSIGR NSKVGEATSI
RKSVIGRNCT IGDNVVIENS YIWDNAVIKD NCVLDHAIVA ADAVIGKNVT LSPGSVIGFN
VVIGDDRVIP NNVKIVETPI IASDGLDTNF GDDEEDESDD EADGDVKHAP ELAAKDIDLV
GEDGKGYAYE SEVDSESYED ESVGGDNYSG IIYQMKSLNF SDESIASISN KRTKTSKHKR
RHSTNSMLSE SGAGPFDSEF EEDEEEDFSK EGYATVIRAI ENNHDIDTAL LELNTLRMSM
NVTYHEVRSV TTQALLNKIV DFIATDTLTP QEAATKIFSR WGTMYKRQVF SPEEQVDLLN
ILESKVLILD NSYNQVILFL AVKTLYDLDV VEEDNILSWW NQGQDSEVRT LTSKFITWLE
EADEEESEEE EDSE
//
