ID   A0A368FDQ2_ANCCA        Unreviewed;       506 AA.
AC   A0A368FDQ2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Hormone-sensitive lipase {ECO:0000313|EMBL:RCN30304.1};
GN   ORFNames=ANCCAN_23922 {ECO:0000313|EMBL:RCN30304.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN30304.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN30304.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN30304.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN30304.1}.
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DR   EMBL; JOJR01001597; RCN30304.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368FDQ2; -.
DR   STRING; 29170.A0A368FDQ2; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR010468; HSL_N.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 1.
DR   Pfam; PF06350; HSL_N; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519}.
FT   DOMAIN          4..268
FT                   /note="Hormone-sensitive lipase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06350"
FT   DOMAIN          284..346
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          425..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  57132 MW;  A28A5960DB7CC28E CRC64;
     MERLQRTNDL VTQLQDIAPS YDYDENTPGN GYRSLVCICD TTVLHIISLQ KTVSEQRGSF
     VFRLAHYCKE LEAFVNVIHF LMDSLPLCIG NAASMPSGSL FPPLHGNYEK YHEMLRGLEQ
     LDSTCFYGRP LGFQFSPSVN RIFRLIGIVL ASYSLSWEKG HGPIGSIINT GRFFLSPEQR
     ASRIIKVTKE ADIDFCKGFW NLAELSNNMP KWFSPNMAIN ELREINWVGP ISLETTKGGK
     VRIPEPSAHT GPRPVQIRVL SPVHRPHMSP TGSSNQQPAS PYIVFHCHGG GYVATSSKSH
     ETYLRMWAKL LNCTVVSVEY SLAPANPFPR PTEEVLFAYA WIVNNPQLVA YTGGYGHSEK
     KEEATDSAGH KSLQEYVEQV QKSQRFDFAI HKRSLSQSLA DTAVLAAGHA LDNLQDWLEK
     PSKEKQKLDR TISHKEPNRT EVEEPCERKS HILDLLNKSV VPRDPLISPM YASDDVIRQL
     PPVYFVVSMY IRRLCDKCQK TSNESM
//