ID   A0A368FEC2_ANCCA        Unreviewed;       647 AA.
AC   A0A368FEC2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Protein VAC14 homolog {ECO:0000256|ARBA:ARBA00013840};
GN   ORFNames=ANCCAN_25729 {ECO:0000313|EMBL:RCN28527.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN28527.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN28527.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN28527.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane
CC       {ECO:0000256|ARBA:ARBA00004524}.
CC   -!- SIMILARITY: Belongs to the VAC14 family.
CC       {ECO:0000256|ARBA:ARBA00010225}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN28527.1}.
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DR   EMBL; JOJR01002530; RCN28527.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368FEC2; -.
DR   STRING; 29170.A0A368FEC2; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0070772; C:PAS complex; IEA:InterPro.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR026825; Vac14.
DR   InterPro; IPR021841; VAC14_Fig4p-bd.
DR   PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR   PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF12755; Vac14_Fab1_bd; 1.
DR   Pfam; PF11916; Vac14_Fig4_bd; 2.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          458..524
FT                   /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT                   /evidence="ECO:0000259|Pfam:PF11916"
FT   DOMAIN          526..592
FT                   /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT                   /evidence="ECO:0000259|Pfam:PF11916"
SQ   SEQUENCE   647 AA;  73208 MW;  B7872FD9F467E6E1 CRC64;
     MADNQYAPLT ANIVRTLTDK LYEKRKAAAL DIEKLVRDLH ATNQLTQLDK LLTVLRELAM
     ASNGHTRKGG LIGLAAAAIA LGKNAPPYTV HLIEPVLSCF NDPDLRVRYY ACESLYNIVK
     ICKVAVLTHF DQLFDVLWKL SADTDQNVRS GAELLDRLLM DIVVSKEDFD IANLMSLIRD
     RIYVQTSSNR KFIVQWLNVM LSTPAFNVLP YVAEVSDGLF RMLADGQPAV RDVTETLLGQ
     FLQGIHNNPD ALSHEDRSQM VSVLLAHAHE DEPPLGRKLA LIWMDEFIRI YKDKMLPYLS
     SYLTAVLPSL DCDTLKAKSV NDYLLTLIEA NTKIEEQTIN CVIEVLLKFV THEKRETRIA
     VLNWIRHLNA TMPSQLFLHM DRIFPVLLGT LSDTSDEVLL LDLHLLSDIC QSNADRYDVD
     LKSFQLSEDT VKNLSPVSPS LVKFAISLLE MFRAEPALLN DRGVLIIRQL CLLMEPAHIY
     RALCVLLLRE QSITFIQNVV SMLHGVLLTA TELFILRDQL RMLEGKVDMT LDVLVEIDKL
     VNMIESPVLA YVRMDLLSAC HQRSLSTVLS ALLMLMPQSD AFHTLHKRLQ AVPALTVVGK
     EVSAPKPKVD FAPLFECLRN ALTRRQTEIR RKHRDVLLAS IQKMSMR
//