ID   A0A368FHT3_ANCCA        Unreviewed;       502 AA.
AC   A0A368FHT3;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=DIX domain-containing protein {ECO:0000259|PROSITE:PS50841};
GN   ORFNames=ANCCAN_22501 {ECO:0000313|EMBL:RCN31713.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN31713.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN31713.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN31713.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN31713.1}.
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DR   EMBL; JOJR01001236; RCN31713.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368FHT3; -.
DR   STRING; 29170.A0A368FHT3; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.240.130; -; 1.
DR   InterPro; IPR043581; Axin-like.
DR   InterPro; IPR001158; DIX.
DR   InterPro; IPR038207; DIX_dom_sf.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46102; AXIN; 1.
DR   PANTHER; PTHR46102:SF2; AXIN; 1.
DR   Pfam; PF00778; DIX; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50841; DIX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW   ProRule:PRU00069}.
FT   DOMAIN          414..500
FT                   /note="DIX"
FT                   /evidence="ECO:0000259|PROSITE:PS50841"
FT   REGION          94..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   502 AA;  56498 MW;  C0C5AEE678516C76 CRC64;
     MSAQRNVQTT ELARSIYQKY ISLRTASCCF NFIPHKLRQE IGVRLKQTGS GFPDPRLFSA
     ILPYLDSFLR QQHEQFVCSE EFLEAFNRVS MGVEDSGDYP SERRRSGVSS KKPQLTAETL
     MKSRHDREHV LGESSLEKMY PTSSMPRPYV CHATTSQNDS AVSSSFSSDA NGHRPARLRS
     IREEHLRGNP TTFAIPRVEH HSKTDTMQFD HNTEEGRKMF AAVICKKLNR VQARRERNDE
     TERQLRDIED RKCTTRELVS TSEAVHDVAC DDDDDVECYL ERMREDSLKA SANRSPRHNA
     LSPRPFSPER DRSKASCGVS GASMGIMSVS MSAYPRSTNQ FAPPPLPNTF NTTGVFYKEN
     RSMNQTAPIY DSSGVESMAP SAFSDTSRGS RRAPLIAQGL GTPRRTRRSL PFTGQQLMTI
     SYKGIDGVPV VAHVPVPQGG LTLKEFRRHF SISSHANVQF FFKSTCEDGS APYQLLLVND
     DSAYLPIFEG RITAELKRIS PE
//