ID   A0A368FQN0_ANCCA        Unreviewed;       336 AA.
AC   A0A368FQN0;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Common central domain of tyrosinase {ECO:0000313|EMBL:RCN32517.1};
GN   ORFNames=ANCCAN_21674 {ECO:0000313|EMBL:RCN32517.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN32517.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN32517.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN32517.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN32517.1}.
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DR   EMBL; JOJR01001076; RCN32517.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368FQN0; -.
DR   STRING; 29170.A0A368FQN0; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11474:SF114; TYROSINASE-LIKE PROTEIN TYR-3-RELATED; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..336
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017025932"
FT   DOMAIN          155..172
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          305..316
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   336 AA;  37959 MW;  DC74ED72E1407674 CRC64;
     MSRAKYLLLW TTAFGWITVI TCIDCSKAPS EALRIVCQQL QRWDDGARKT PAPTSVKPPS
     IGGKVQLAAD FAPIASNMYQ CMDIACLCVF FRGSGGASCT VQGRPLRKAL RKEYRQLTDD
     ERNRVHTAFR TIKSSGEFDR LARIHAQFAS SGGAHSGPAF LPWHREYMKR VEIALRQVDP
     EIALPYWDST LDENMPNSKD SIMWTNEFMG ETTGGSVSGG PFREWRTLEG RPNIRRDVGA
     KGKCFSEDEI QFMMGQTDIS QVLAFTSPKQ GCPFQPNFNV IEYTHGNPHI YVGGEMFDQA
     TAGNDPVFYM HHSFVDYIWE MWRQSKQDWS LIQGQA
//