ID   A0A368FVI9_ANCCA        Unreviewed;       663 AA.
AC   A0A368FVI9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=Alpha-2-macroglobulin family protein {ECO:0000313|EMBL:RCN36193.1};
GN   ORFNames=ANCCAN_17929 {ECO:0000313|EMBL:RCN36193.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN36193.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN36193.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN36193.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN36193.1}.
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DR   EMBL; JOJR01000579; RCN36193.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368FVI9; -.
DR   STRING; 29170.A0A368FVI9; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.1930; -; 2.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 2.60.40.2950; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   PANTHER; PTHR11412:SF175; TEP (THIOLESTER CONTAINING PROTEIN); 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   SMART; SM01359; A2M_N_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..663
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017074499"
FT   DOMAIN          512..648
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
SQ   SEQUENCE   663 AA;  73331 MW;  C6BE1963C6B9FD0E CRC64;
     MIIAVALVAL IPLLPHVVAQ ESTTELFKED VTKEAPTLPT LPTTTTEAPK IYAGTYMVVA
     PAVVRPGLPY AVSFNILKSP EEDHIVRVQI RTEQNDTVAT RVVKNVRQGI PQTVTIDTVS
     ADLSPSMGYK VYVRGETLNS QVLFEEEKSV QYNQKSLSIF VQTDKAIYKP GSVVKYRVIV
     VSPTLTPYKD TVTVKVYDPN QNVISQYIDK PLTKGVFSSE LELASEPPLG EWQIQVETAN
     KLKYTKTFSV EKYVLPKFEV NIKTPSFITV NDDLSILVDA KYTYGKGVAG KAKVTLELPW
     HRWHPIPKPI IVNDDGTTSQ VEEESQIERT VKLNNMGEAT VIFTNEEMKK HKLVQDYGGG
     SIRIIATVTE DLTDIQRNGT QHISTYRYDV KLDVEKQGDT FKPGLTYNVV VALKQMDDTP
     VKATVPRRVQ VTTFYNYPFN PDAPTQHEDK EVKIVDLDAH GTTVLALQPP LNCTSARIEA
     HYDRSGKDNF TNAVIYSSLY VEAGKSPSNS FLQLIADNEG AVDVGKTLSF SVKATENVPV
     LTYQVMSRGA IVLSKEIPVN SDHTTISFTA TNDMAPKSRL IVYAIRSSNQ EILVDATDFK
     VDGLFRNNVT LSIDKTSVEP GDSVSFKVTA DPDSYVGLLA VDQSVLLLKS GNDITPQLVF
     PTP
//