ID   A0A368G5S6_ANCCA        Unreviewed;       936 AA.
AC   A0A368G5S6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=Patched family protein {ECO:0000313|EMBL:RCN39781.1};
GN   ORFNames=ANCCAN_14303 {ECO:0000313|EMBL:RCN39781.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN39781.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN39781.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN39781.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN39781.1}.
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DR   EMBL; JOJR01000321; RCN39781.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368G5S6; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF124; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        426..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        533..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        754..770
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        777..796
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        802..827
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        848..872
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        884..906
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          316..451
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   936 AA;  105556 MW;  D3EABEEDFDF8D4AC CRC64;
     MVLKRIKWAP LEKPWAELVA RYCIFVARHP WPFIIVPCIL TAILSTGIFL NFKIVRGVYY
     LYSPLDARWK TEEAVFGENW ASDDEHFYPG KDVLRRRGLY LIVQAKDGGD VLRKEHAAQF
     LETLKWVTTA KFLSSEGKRF SYSDVCLHFQ NECFSNTHAR LIADVYSKGD QDHFNMTYPM
     YYTRFATEPI DVSRTLGGVT LNGDKVASAK AWLVLFQLKH HQPKIERLSA DFENSVVRAI
     EAGAAPGPLL DIFYFHSDTF EQELANENKR LTPMFSITFS VLILFSILCT FNLKWISLPS
     GVFAFSSDAS VKILVIDWVL SKPFMGIVGV VSALMAIISS TGLLLLFGVT FVDMCTVMPF
     LSLTIGIDDS FLMLAAWHET PRHFSVVDRI GTSMKHAAVS ISITTLTDAL AFLIGAIAPL
     PAVKYFCFYS CAAIVFIFLY CLSMFVACLA LQGRLEARNH NSLLMNPVKD VGRPEKLTVW
     DLAFHMGSII EDVPEVEYIN NNDVKHESSY KQDANKVEAV DRRMWYQRFF EDYYAPFIAN
     KWMVAFSVLL FSCYVAAAAV GSQQVVVGFD LINIVLAESR PRRFLEVRKK FFPEDFSRLD
     IAVMKPPRME LASERGPFMK VLQKFESTPC SAGRNSTEFW YFSFKTYIEK LGFGDAWSNV
     EEDEESFAEN LHGFLMANDK FSYDILKDSN GSTKAFRFTT GLSNVSTDEL IYRCATMIRG
     LCDDNPQYGL STYTPLWNLA DQFEIMWPQT IQDLYISIAV MLCVAMLFIP QPLCAPLIGV
     SIASVALGVL GIMPYLGVNL DATSMITIAM SVGFSVDFAA HVSYAFMTQK ITDNSQENPS
     FLRLRATLGT VGWPIMQASL SVLLGISSLS FVDSYVVQTC FKTVILVITF GIVHALLFLP
     LVLMYAHKTY LACAASHRRS QRKISPTKEV ENCQKF
//