ID   A0A368GCX6_ANCCA        Unreviewed;       138 AA.
AC   A0A368GCX6;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Mitochondrial pyruvate carrier {ECO:0000256|RuleBase:RU363100};
GN   ORFNames=ANCCAN_11776 {ECO:0000313|EMBL:RCN42263.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN42263.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN42263.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN42263.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000256|RuleBase:RU363100}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC       ECO:0000256|RuleBase:RU363100}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC       2.A.105) family. {ECO:0000256|ARBA:ARBA00006416,
CC       ECO:0000256|RuleBase:RU363100}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU363100}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN42263.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JOJR01000203; RCN42263.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368GCX6; -.
DR   STRING; 29170.A0A368GCX6; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IEA:InterPro.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363100};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU363100};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW   ECO:0000256|RuleBase:RU363100};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363100};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363100};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363100}.
FT   TRANSMEM        101..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363100"
SQ   SEQUENCE   138 AA;  15525 MW;  D3D9F6B0E6C957B4 CRC64;
     MITLSRMGLP QILYRTLCGI GDRVVYPLLP GFAKSAWNHP AGPKTVFFWA PTIKWGLVIA
     GIADLARPAN KLSVSQNSAL MFTGATWARY SFVIIPVNYY LASVNMFLFT TGFVQLCRIA
     NYRRNDPQRK QIAHEEKS
//