ID   A0A368GMA7_ANCCA        Unreviewed;       948 AA.
AC   A0A368GMA7;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Transporter, cation channel family protein {ECO:0000313|EMBL:RCN44778.1};
GN   ORFNames=ANCCAN_09217 {ECO:0000313|EMBL:RCN44778.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN44778.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN44778.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN44778.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN44778.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JOJR01000120; RCN44778.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368GMA7; -.
DR   STRING; 29170.A0A368GMA7; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR   PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        482..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        516..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        545..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        612..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        654..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        780..799
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          164..220
FT                   /note="RyR/IP3R Homology associated"
FT                   /evidence="ECO:0000259|Pfam:PF08454"
FT   DOMAIN          611..808
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   948 AA;  107862 MW;  6235F01A9851A104 CRC64;
     MEERSLYDIQ CRLNEAGASD LVIDIIINEP SREIFLKAIQ LAKALLLEGN DKVQQSFYNR
     LKKKDTHEPF FTALSHRIQT AQNRLKSDMM SCNENKPKGA STVLTPVLDH GAHIPFSGTL
     FDANHMRHPS LSEISNHSHD MTASVPDLSP YQDEERTNDA LPPEVSIIEP ILRVLQLLCE
     NHNSLLQNFI RRQSDRANHN LVAETLSFLD TVRLSNLYPN QQENGRINCL SLQSQASKLL
     LAIMESRHDS ENADRVLQNM DNTDGGPRQL VHAITQAYEM AHSKQYEINQ MKKELLQRAN
     LQDRPRSVVS PLIKTESVTL PEISVDASGT VSIHDDAKSE LKYVSEEATS VDPKEVGHNI
     YILAHQLSRH SSELAEYLNP DDEKKSSKTR NALSFYKKHT AQIEIVRQDR KLERVVFPIH
     EICSFLTKET KQNVYNNTEK DAQGSKVTEF FDQWPALYEE MKWQRKLQDR PYLSACTQRL
     RLWGRLAFLF AVLVNTIIAL YYPFETADTG LYASNPFMYT SVVISIIFLY SQWDENSSLA
     KSSNIITAIA AVMFSAAILL ISLFGLVPAL YIIGAAQLTN KCVHLVAYAS NKGLEDKSWS
     VRLSDGELHY HLVYLVVCFL GLFVHPMLYC LLLFDIVASE ETLRNVISSV TKNWQSIILT
     GLLALILIYI FSIIGYSFFQ RDFIREVDRL EPEPPATVFV KDPNPETCAS DGECPPPAPV
     VVEEKKEGDG EDKIASCETL RMCIITTLNW GLRNGGGIGD VLRNVAPEEN LFYYRIIYDL
     SFYVVLIVIV LNLVFGVIVD TFGDLRTEKN DKEDVLKNSC FICGLERGKF DNRSVTFEDH
     QAEEHNLWHY LYFIVWLQIK DETEFTGPES YVAQCIKERK LDWFPRMQAI SLQDGDSDSD
     QPEITAIREQ LRLQNQSIRE LTATIDDLRQ VGRRSSSCNK IFGCNGLL
//