ID   A0A368GSX4_ANCCA        Unreviewed;       448 AA.
AC   A0A368GSX4;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=Patched family protein {ECO:0000313|EMBL:RCN46389.1};
GN   ORFNames=ANCCAN_07567 {ECO:0000313|EMBL:RCN46389.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN46389.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN46389.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN46389.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN46389.1}.
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DR   EMBL; JOJR01000080; RCN46389.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368GSX4; -.
DR   STRING; 29170.A0A368GSX4; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF112; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        214..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          216..373
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   448 AA;  50458 MW;  6D9B90BB94FC6CAA CRC64;
     MGGGVVRFKE VNNVRDHFSA ADSPSRYEFA VAREFFQELG SPFHVVVALK AADEGNILRP
     KYIDKALEIE DFLQYKLKIE HENRSYAYSD FCGTQCETSD AVSIFLTMFR DQQQKGTNHV
     KLTYPSMDVF GHRVYLANNI FLVKTNNLSQ IVEESGLVAI NFHAIYNNES SVAIMRKWEK
     AVFEYSQSTI NDPLIRVFCT SEGLVSEEVR RTGILAMPLM GVTFLILMVF TISTTLRRDP
     VKSNPLEAFL GVICPILSLV ASFGNLFWLG FEFLPIVTVV PFLILAIGVD DVFIFIHAFH
     LTNEKHTVRE RIAETLADAG PSISITSLTN LLSFGIGVLT NTPAIYTFCV FISVAVVYDY
     IYQIFFFSAV LTLGGQREAR RGNAYLCCLT VPPETKKEKQ RKPNWLVRTA SKLLDVILDA
     WVDFSLSIWS KFIVGGQFCT RICADILV
//