ID A0A368GXV9_ANCCA Unreviewed; 848 AA.
AC A0A368GXV9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Trypsin Inhibitor like cysteine rich domain protein {ECO:0000313|EMBL:RCN49202.1};
GN ORFNames=ANCCAN_04775 {ECO:0000313|EMBL:RCN49202.1};
OS Ancylostoma caninum (Dog hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN49202.1, ECO:0000313|Proteomes:UP000252519};
RN [1] {ECO:0000313|EMBL:RCN49202.1, ECO:0000313|Proteomes:UP000252519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Baltimore {ECO:0000313|EMBL:RCN49202.1,
RC ECO:0000313|Proteomes:UP000252519};
RA Mitreva M.;
RT "Draft genome of the hookworm Ancylostoma caninum.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCN49202.1}.
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DR EMBL; JOJR01000037; RCN49202.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368GXV9; -.
DR STRING; 29170.A0A368GXV9; -.
DR Proteomes; UP000252519; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 11.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR PANTHER; PTHR23259; RIDDLE; 1.
DR PANTHER; PTHR23259:SF77; TIL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01826; TIL; 11.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF57567; Serine protease inhibitors; 11.
PE 4: Predicted;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT DOMAIN 62..102
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 189..222
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 327..367
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 393..429
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 449..489
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 575..611
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 634..670
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 694..730
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
SQ SEQUENCE 848 AA; 93494 MW; A2814C8847E0E0B9 CRC64;
MAKKSFDIQK FSVYHLDVSY LPGIRFFKSL LLLTAVDALH GHDQFAIPRP FRRCFANEEF
SECASPCEPT CKDPNPGVCT MQCIAGCQCK PGFLRNENGA CVADCKNESL KPMCRPNEEF
KECGTACEPS CREPRPKICT LQCVVGCQCK NGFFRNDKNE CVAECDNASA NICPENEEFK
QCGTACEPTC ENPRPLICTA QCIVNVCQCK PGYFRNSQKK CVAQCGSESH IMPIASLNEE
GSTTASSVQR TTRSNTCGVN EEKKACGTAC EPTCENPNPT CSKKCVPNVC QCMDTFLRDS
NGKCIPEEWC PKRPEEEACG TNEERVECGT ACEPTCSDPK PVCTKQCVKN VCQCRFGFIR
NSKNQCIPTN ACPPSVPEKP CGTNEERKKC GTACEPTCAN PNPRCTKQCI NNVCQCRFGF
IRNSKNQCIP TNACPASERP CDKNEERVEC GTACEPTCAD PNPTCTKQCI KDVCRCRFGF
IRNSKNQCIP TNACPAPAVA TIISTFDFHP RRFSSTYRQT FSFSRVSYYA DCCVGECRNN
RSPYCTAFYP FQKDCYSLHS DRCGVNEELK TCGSACEPSC ANPNPVCTTQ CIANVCQCMD
TFLRDSNGRC IPEEWCPKEQ PCGTNEERVQ CGTACEPTCS NPNPVCTKQC IKNVCRCRFG
FIRNSKNQCI PTSACPPSER PCGTNEERKE CGTACEPTCA NPHPTCTKQC VKNVCQCRFG
FIRNSKKQCI PTSACPPSET TTMPPADCNT LRCPQGTACI MVQESCSRRP CPPPTPKCVP
STMNPPMMCG PHETWKSCSG CEPTCTNMNP ACGFSCGEPR CECDPGFFRS RLGPCVTMQE
CRRNVGHR
//
