ID A0A368H2Z1_ANCCA Unreviewed; 2398 AA.
AC A0A368H2Z1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=CUB domain protein {ECO:0000313|EMBL:RCN50946.1};
DE Flags: Fragment;
GN ORFNames=ANCCAN_02959 {ECO:0000313|EMBL:RCN50946.1};
OS Ancylostoma caninum (Dog hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN50946.1, ECO:0000313|Proteomes:UP000252519};
RN [1] {ECO:0000313|EMBL:RCN50946.1, ECO:0000313|Proteomes:UP000252519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Baltimore {ECO:0000313|EMBL:RCN50946.1,
RC ECO:0000313|Proteomes:UP000252519};
RA Mitreva M.;
RT "Draft genome of the hookworm Ancylostoma caninum.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCN50946.1}.
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DR EMBL; JOJR01000018; RCN50946.1; -; Genomic_DNA.
DR STRING; 29170.A0A368H2Z1; -.
DR Proteomes; UP000252519; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 9.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 11.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46908; CUBILIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR46908:SF4; TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN; 1.
DR Pfam; PF00431; CUB; 7.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00042; CUB; 11.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 11.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 11.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 90..127
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 129..170
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 223..262
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 307..353
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 356..394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..432
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..560
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 564..681
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 687..885
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 885..1012
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1016..1133
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1298..1421
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1422..1553
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1555..1613
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1692..1841
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1967..2037
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2229..2354
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 117..126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 160..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 384..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1422..1449
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RCN50946.1"
SQ SEQUENCE 2398 AA; 267188 MW; 14F64291F749BB28 CRC64;
LKAQFTALQE KVEAISTRQD TFKSRVDSHQ STLILVATAS RRLLQSSKNF TAELRQLQEW
RQNKTAKDVR LRRFMGRLQK SIKALADMLA MDGCESKPCQ HGGTCLPRFG KKYNCLCPPY
RTGDNCEEDV DECAIYEGTH AGCQHNGTCI NHDTGFRCEC RSGYHGPLCQ YRQSTCSRKR
CCLFSISSSR TLNKVKCLQA SYKCICDWGY KVSDDKQNPT CVDVNECLDN PCHPGVDCIN
LPGKFQCVGC PKGYHGNGQI CADIDECAAE TYPCSTNPRV PCFNTIGSFH CGSCPPGYSG
DGRSCRRKSA CDAAPCHPSA TCVDDQTTLN VGGFTCHCPA GMMGDGIGED GCQKSNSTIC
RTEGNCMNGG TCKPISAAEY RCLCPEFYYG LHCEQVSACI GTPCENGGIC QDAGVGKVNC
VCPIGFYGSL CQFEENSCGA HYTESSGNLT FPTDTESVAA EGCDFVISTA EENSALKITF
IAFKDMYGSD VGSTDCTKTP ANLTLFDGAS DNAPIFATFC GDSSSGKAPV IGEAITMTSS
SAMLRYKGTG GSFSIKWETK KRECGYRTNL ASGVLVVPQH HMDMVCDWFI SAPMEKHIEI
EIPSVEMNTG LELNCSANEL EVFDGYTSYD AHRIVHICET TNVTTLVRST GPFLTVSFRN
NVFGGSKSAL HRGFTMKYRT IEPDRRCGGD ITNTDGDWDF SGMIDSPNYG GFYPPNMDCS
WKLDGIGPGN TSTTDQTLKL EFISFDVPSA YQFSSAMWQQ QIDIPRRAFN IFSSIERKFN
DFLVCLHDPC PSRDGNEPEA LVLGRMGLVS PFRRVNPLIP FRRQMVYQCT EDYLHLYADG
QLIHDGCNAH RPPASMLMPL PQVILRFHSD SSTQGKGFRI AYSLVCEKTL YGNGTIQTWN
YPDGGRAGKC TYIIRADLSH AIRLKFKTIG MRGATTSQCF YNRDAHETAT DYVEFSGGKE
EDKQINRRYI CARYPFVEEG EFIMSATRPL VITYVSSGDE KNRGLLMEYT TTDVGCGGVF
SQSTGTISSP NYPDKYLPHM HCVYQIQVAW SKQVRLTFDN FDIEVVQNDE CSYDNVAVYE
SYVSPSEHGK LLGRFCGTML PPTLLSSTYK MAVVFSSDRS IAGNGFSARF EGIDPSTDCD
RTYTAPAGEI IFDGTQGRYS QCDFHISVIS TARLVLKMNN MSIPCLKSQL ILRHVCFVMY
FDVAFFLIHE TCRQINTADF YSFTSSRSTP EYPMTFLRNG VSDQSPGFAS LNAESSICDE
YTMPVLRSHG SRVFLRLQTT DSSKTFFNIS YEQIISTCGG HVEGVSGSIA APQYPLKDSR
SLDCSWTIAV ALGNHVRFSL VNIDDLKSSD DNGFCGMFAA NRLDVLDGPH SDARLMRRYC
RRVVGAEPLT SEDHEIAVRY KQHGGPMLGP LFGFMAHFST VCTDIVLTDF MGSIQTPGYP
NKVWTGQYCS WTIKVPPGNR IQLNFHNFVV DRRFRYGALP GKCAENWLKF GEGEVAEATV
KIGNSINVTN KLTEACSDVA KPMVVKSKNN VMHLTYQSKK QEQNHFWLTW TTIGCGGKLI
TASNISANVN RMDSNAEQLE CEWQILAPVG KRIVLNVNTL SIFQKTEVSC QYNDENEEFT
GLAIFSGPSN RSGYPQYTAC TSLRNLTYTS HTNEMFLMLK YQMKSVMADS EGNFFVANVT
FVDADANNKD ECGGVVEVSP TQPSSIHSPR FPEEYERGTE CQWLFKAPPG YYLIYTIKEY
ITPNAHEQQT EKKWIPRAIN NLTCQDPLPL IEGALTIYGG NTTKSEKIER VCLDIEEPKQ
VPVFAAESLV TFRGASTARI HMTGEDQHVR RVGFLLEAKT ACGGLVLAED MENVMTFSDL
EEEVCNITIR KKNESASGIY VRLDEFVSRG ITKHRSSDMM FGNSYLDIQI DGGDVMSREA
RGPYLVEAST THEEFRAKNE IRISFVKKNS LLAARMVIAY STVIENCGGE ITSREGFIGI
PDIDGDFDCV WTLRENPGNG VRASVTELRV PFSPNCTDSY LEFRKWNASG PLIGRWCEKA
PSMFGMEEVI WMKFRYTKPK DADSDEDLVK PNMRILFSRL HGGTTTSHVI QQPLVLIEEM
YTNFMWIAEG EPDKALLVHI DSIRIPEENY EGYDGINKIG LFLSEALDNP NLNFIMNNGR
PGSVRVAGFV PPADIYLPFS RLEVSFFAPP RSAFRLTWKS VPKRSANHTE EEEAKNATKD
YNYSSVYACG STLVPIWEWQ EITNPVPAGK TSGYENNVHC KWTIERPLMT GLRVKIKMLD
LEDVGGCPFD FISLLPDRDA EESSGDEFNS GQKYCRSSHV NTTLDYSYNK VLYVHFVTDR
SRTGRGFVLQ YRLTCNSFDY IRPSYGLLDH VLTSPGYPKP ETDQASVHKV SFTLSFNG
//