ID   A0A368HBI9_ANCCA        Unreviewed;      1068 AA.
AC   A0A368HBI9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Peptidase, S9A/B/C family, catalytic domain protein {ECO:0000313|EMBL:RCN53058.1};
GN   ORFNames=ANCCAN_00607 {ECO:0000313|EMBL:RCN53058.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN53058.1, ECO:0000313|Proteomes:UP000252519};
RN   [1] {ECO:0000313|EMBL:RCN53058.1, ECO:0000313|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore {ECO:0000313|EMBL:RCN53058.1,
RC   ECO:0000313|Proteomes:UP000252519};
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCN53058.1}.
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DR   EMBL; JOJR01000003; RCN53058.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A368HBI9; -.
DR   STRING; 29170.A0A368HBI9; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR025066; CCDC174-like.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF13300; DUF4078; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000252519}.
FT   DOMAIN          439..739
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          869..1067
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          219..247
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        152..176
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1068 AA;  119892 MW;  D58DE427372E70E6 CRC64;
     MATFASTAMS KNLAEGEEVA EPVKKKYEPK KLHTNEVASL FDLKSEYLKK KNDIVQSATG
     EVYRGGKSSV LAVNKEEKVS IKKEAQERKR RINEHEAALR KEEEERLDLV RKKLKEKSEL
     YEKLSEGKVT LQTSDGLDVE FLVDFNAKVK ERQESQQSQP TYHEELPTTS TSSEPAPLVE
     HYVPEEERRE YGVSHMKFSS EEEKRQAQIK SLYDMTAETE KMRAKNRSVA DEKARAKREK
     LNALRRRKGL PEIRTPSPEP EPEQPEVNLE EIPLPIEKPL RMAPLERSPT PNVPWHQLVA
     HARLLRAELR SSLALPFSRM SIVATKTGCR LYALGTPVCS SNQTVLSAEI PADGGSSNIV
     LEPMFSPDQF KAATPSVEFS LMCERQRATV VSGVTDYMVD SDGSNLMLTT GEQVFRYSDG
     NIVPLAVGGG SNDSGAAGGF VFDTQFCPCD SKLVSYVLNK QIHIEREGSL LYRTSSTDPN
     ISNGVPAFII QEELDRFQAV WWSPTSTRLL YERVDETAVR SLMFVCPGRE APAPMKYPVA
     GTENHTSQLR LIIIDGNAVL DCGLKVPLKT RYPWVEYIAR AGFLNDGKTM WVQIMNRTQS
     QAALIILPES EFEGITSSGP IREASIVKDE VSTAWINNHN AIVPLDGNPS TIEFIYASEQ
     SSHCHLYFIS AHIIDNDVAD LRERVVTQGD FSVCKATSVV IDKDRRLVYY IANVATPTEW
     SVCVSSYDES VNEMRRLTER GLSFKGERAC HHLCLLPSNG FACWMTSLSQ PPQCRYYSLV
     FSEDSILPNA TLVAQIGLSG YNLPATVQIN DIPVIVEYQS RNMRRYAMVM RPANFEPGRS
     YPVLHYVYGG PGIQLVRNDY STWIPFQKYT KLGFVVVMLD GRGSSNRGTE FEFPIFGKLG
     QCEVEDQVEG LQEVAQIMDG MLDLSRVVVQ GWSYGGYMSL LALAKYPHVF RAAIAGGAVT
     DWKLYDTAYT ERYLGYGSER DPFYEESSVI KHVEKLPDQP GRLLLVHGLL DENVHFRHTE
     ALIEQLIKAG KPYQLQLFPS ERHGIRSSDG AAHLDASMLN FIQQALKD
//