ID A0A368HF01_ANCCA Unreviewed; 530 AA.
AC A0A368HF01;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=EGF-like domain protein {ECO:0000313|EMBL:RCN53795.1};
GN ORFNames=ANCCAN_00289 {ECO:0000313|EMBL:RCN53795.1};
OS Ancylostoma caninum (Dog hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=29170 {ECO:0000313|EMBL:RCN53795.1, ECO:0000313|Proteomes:UP000252519};
RN [1] {ECO:0000313|EMBL:RCN53795.1, ECO:0000313|Proteomes:UP000252519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Baltimore {ECO:0000313|EMBL:RCN53795.1,
RC ECO:0000313|Proteomes:UP000252519};
RA Mitreva M.;
RT "Draft genome of the hookworm Ancylostoma caninum.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCN53795.1}.
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DR EMBL; JOJR01000001; RCN53795.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368HF01; -.
DR STRING; 29170.A0A368HF01; -.
DR Proteomes; UP000252519; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45836:SF4; PROTEIN SLIT; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000252519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 141..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 178..215
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 217..253
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 342..379
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 382..530
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 205..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 243..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 283..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 321..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 346..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 369..378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 530 AA; 58612 MW; A5985295C2976D32 CRC64;
MFRDMSHNRV ESIEDGTFAN LTKLSTLILS YNKLRCLQPR SFAGLHSLRI LSLHGNDISL
LPETAFESLG NITHIAVGSN SLYCDCRMEW FSRWIKSKFV EAGIARCVAP ANVANQLLLT
ARSHQFQCGG VVPASVSAKC DACVTAPCKN GARCETTSGR DYRCHCAAGF HGKDCENEID
ACYGHPCLNN AVCKVIQEGR FTCVCPKGFR GDYCEVNIDD CEKNKCQNGA RCIDLVNSYR
CECGPMFRGK YCEEKLEYCS KRLNPCENGA KCHRMGSDYK CECLPGFTGR NCSTNIDDCG
DHQCINGGIC VDGITTYSCQ CVMGFSGQFC EIPPMGNALY PNTAQCHSLL CGHGSCYTNE
DMSEYECRCH EGYAGDKCDK IRSIGLHHPS AYVALEPWAV ESGNLSFAIR TSNESGLIAY
YGDDSFISVE LYDGRIKIAF YIGNYPASHM YSYVTVNDGL AHRIEILVQG KKCSLSIDNQ
TLQSIENDGK LENFSIDTKQ YLYIGGLPAD RAARVKSMFH VKESHSFKGN
//
