ID A0A368KYS0_9BURK Unreviewed; 940 AA.
AC A0A368KYS0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316, ECO:0000256|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156, ECO:0000256|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205};
GN ORFNames=DU000_11375 {ECO:0000313|EMBL:RCS56560.1};
OS Parvibium lacunae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Parvibium.
OX NCBI_TaxID=1888893 {ECO:0000313|EMBL:RCS56560.1, ECO:0000313|Proteomes:UP000252357};
RN [1] {ECO:0000313|EMBL:RCS56560.1, ECO:0000313|Proteomes:UP000252357}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KMB9 {ECO:0000313|EMBL:RCS56560.1,
RC ECO:0000313|Proteomes:UP000252357};
RX PubMed=29498621; DOI=10.1099/ijsem.0.002667;
RA Chen W.M., Xie P.B., Hsu M.Y., Sheu S.Y.;
RT "Parvibium lacunae gen. nov., sp. nov., a new member of the family
RT Alcaligenaceae isolated from a freshwater pond.";
RL Int. J. Syst. Evol. Microbiol. 68:1291-1299(2018).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000, ECO:0000256|HAMAP-Rule:MF_00205}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCS56560.1}.
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DR EMBL; QPGB01000006; RCS56560.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368KYS0; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000252357; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00205};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Reference proteome {ECO:0000313|Proteomes:UP000252357};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205};
KW SOS response {ECO:0000256|ARBA:ARBA00023236, ECO:0000256|HAMAP-
KW Rule:MF_00205}; Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00205}.
FT DOMAIN 604..936
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT ZN_FING 253..280
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT ZN_FING 739..765
FT /note="C4-type"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
FT BINDING 640..647
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205"
SQ SEQUENCE 940 AA; 104479 MW; B6B833661E6BB188 CRC64;
MNTEIKVRGA RTHNLKNINL DIPRDQLVVI TGLSGSGKSS LAFDTLYAEG QRRYVESLSA
YARQFLQLME KPDVDLIEGL SPAISIEQKA TSHNPRSTVG TVTEIHDYLR LLYARVGTPY
CPDHPEQSLE AQTVSEMVDH VLALPEGTKL MVMAPVVRER KGEFVDLFAN MQAQGFVRFR
VDGQIVEADN LPKLKKTEKH NIDVVVDRLK LNPEFKQRLA ESFENALRLA EGRALALEMD
SDKEHLFSSK FACPICSYSL QELEPRLFSF NNPMGACPTC DGLGQVQFFD PKRVVQFPNL
SLGSGAIKGW DRRNQFYYQM LTSLANHYEF DLDSPFEKLP DNIQHLVLYG SGKEKVPFAY
VGERGKTVIR EHAFEGILPN LERRYKETDS MAVREELAKY INSKPCPDCH GTRLRKEARF
VKVASEPIYA ISAWPLRNAL EFFTDIRLKG AKAAIAEKII QEIRSRLQFL NNVGLDYLCL
ERSADTLSGG EAQRIRLASQ IGSGLTGVMY VLDEPSIGLH QRDNDRLIGT LKHLRDLGNS
VLVVEHDEDM IRAADYVVDM GLGAGEHGGC VIAQGTPKEV QKAKGSITGQ FLRGERGIHV
PEERRQPDPE KQLVITGASG NNLKNVTLNL PVGLLTCVTG VSGSGKSTLI NDTLYHAVAQ
HLYNSSTEPA PFEEISGLEH FDKVINVDQS PIGRTPRSNP ATYTGLFTPI RELFAGVSTA
RERGYEAGRF SFNVKGGRCE ACQGDGVIKV EMHFLPDVYV PCDVCHGKRY NRETLEVQYK
GKNIHQVLEM TVEQAHEFFN AVPSIKRKLQ TLLDVGLGYI RLGQSATTLS GGEAQRVKLA
LELSKRDTGR TLYILDEPTT GLHFHDIELL LKVIHTLRDH GNTLVIIEHN LDVIKTADWL
IDLGPEGGAG GGQILVEGPP EKIAASKQSF TGQYLGPLLK
//
