ID A0A368MW92_9FLAO Unreviewed; 632 AA.
AC A0A368MW92;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=DQ356_10180 {ECO:0000313|EMBL:RCU42286.1};
OS Chryseobacterium lacus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=2058346 {ECO:0000313|EMBL:RCU42286.1, ECO:0000313|Proteomes:UP000252172};
RN [1] {ECO:0000313|EMBL:RCU42286.1, ECO:0000313|Proteomes:UP000252172}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YLOS41 {ECO:0000313|EMBL:RCU42286.1,
RC ECO:0000313|Proteomes:UP000252172};
RA Li C.-M.;
RT "Chryseobacterium lacus sp. nov., isolated from lake water.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCU42286.1}.
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DR EMBL; QPIE01000007; RCU42286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368MW92; -.
DR OrthoDB; 9802808at2; -.
DR Proteomes; UP000252172; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd01030; TOPRIM_TopoIIA_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR PANTHER; PTHR45866:SF2; DNA TOPOISOMERASE (ATP-HYDROLYZING); 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RCU42286.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000252172}.
FT DOMAIN 414..524
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 632 AA; 72716 MW; DF73C8B8FF00D623 CRC64;
MNENTTVQYN EDNIKTLEPR EHVRLRPGMY IGKLGDGSAS DDGIYILLKE VIDNSIDEFR
MKYGKKIEVK IKDGRVVIRD YGRGIPLGKI VEVVSIMNTG GKYDDGAFKK SIGLNGVGTK
AVNFLSEYFQ VKSVREGKMR RAEFQDGKLI ELHDEAETTE RNGTEITFIP DETIFINYKF
RSEYVERMLR NYSYLNLGLK IYYNGEVFES QNGLKDLLEE EIDSEIVYPI IHIKDEDMEI
AITHSDKSQS ETYFSFVNGQ YTSQGGTHLN AFKEAYVKTI REFYGKNFEA ADIRKAIIGA
VYINIGNPVF ESQTKTKLGS STMGQDKNGN ELETIKTFMI NYMKGKLDNY LHKNPEVAEA
IQRKILISER ERKELSGIQK LARERAKKVS LHNKKLRDCR QHYNDQKASR KAESQIFITE
GDSASGSITK SRDVETQAVF SLRGKPLNSY GLTKRVVYEN EEFNLLQAAL NIEDSLEDLR
YNQVIIATDA DVDGMHIRLL MITFFLQFFP DLIKNGHLYI LQTPLFRVRN KKETRYCYSD
AERIKALNEL GKNPEITRFK GLGEISPDEF KHFIGKDIRL EPVVLGKDQT IEQLLEFYMG
KNTPDRQTFI LQNLVVENLD IDQKQKLEEV EV
//
