ID A0A368N6U3_9EURY Unreviewed; 344 AA.
AC A0A368N6U3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:RCU45946.1};
DE EC=1.2.1.11 {ECO:0000313|EMBL:RCU45946.1};
GN Name=asd {ECO:0000313|EMBL:RCU45946.1};
GN ORFNames=DU504_00680 {ECO:0000313|EMBL:RCU45946.1};
OS Haloplanus salinus.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloplanus.
OX NCBI_TaxID=1126245 {ECO:0000313|EMBL:RCU45946.1, ECO:0000313|Proteomes:UP000252189};
RN [1] {ECO:0000313|EMBL:RCU45946.1, ECO:0000313|Proteomes:UP000252189}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 18368 {ECO:0000313|EMBL:RCU45946.1,
RC ECO:0000313|Proteomes:UP000252189};
RA Kim Y.B., Roh S.W.;
RT "Genome sequences of Haloplanus salinus JCM 18368T.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCU45946.1}.
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DR EMBL; QPHM01000001; RCU45946.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368N6U3; -.
DR OrthoDB; 38238at2157; -.
DR Proteomes; UP000252189; Unassembled WGS sequence.
DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:RCU45946.1}.
FT DOMAIN 4..131
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 150
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 242
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 344 AA; 37137 MW; D816A507C32F1D5E CRC64;
MTVRVGILGA TGAVGQRFIQ LLDDHPTFEL AALTASEDSA GSPYRESAKW RVDSPIPVDV
AEMTVRRTEP DAVPDDVDLL FSSLPSSVAV DVEEDFARAG YVISSNSSND RLAEDVPLTI
PEINPDHLDL IEVQRDERGW DGALVKNPNC STITIIPPLA ALDEFGLDRV NVSTLQAVSG
AGYSGVTSME IIDNALPHIG GEEDKMETES RKLLGEFDGA EVSWHDMDVA ASCNRIPTLD
GHLENAFVDV ADDPDPSEIE DAMREFPGID LPSAPNQLIH VFDDPERPQP RMDRMRGGGM
QICVGGIQET PQGVKFNCLA HNTVRGAAGA SLLNGELLHE NGYL
//
