ID A0A368P2P9_9FLAO Unreviewed; 738 AA.
AC A0A368P2P9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:RCU56808.1};
GN ORFNames=DU428_10665 {ECO:0000313|EMBL:RCU56808.1};
OS Oceanihabitans sediminis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Oceanihabitans.
OX NCBI_TaxID=1812012 {ECO:0000313|EMBL:RCU56808.1, ECO:0000313|Proteomes:UP000252249};
RN [1] {ECO:0000313|EMBL:RCU56808.1, ECO:0000313|Proteomes:UP000252249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S9-10 {ECO:0000313|EMBL:RCU56808.1,
RC ECO:0000313|Proteomes:UP000252249};
RA Li C.-M.;
RT "Oceanihabitans testaceum sp. nov., isolated from marine sediment.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCU56808.1}.
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DR EMBL; QPIG01000004; RCU56808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368P2P9; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000252249; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RCU56808.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000252249}.
FT DOMAIN 404..465
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 738 AA; 84050 MW; 60FB34CC597AB21A CRC64;
MTEVDIEKEN AAITKAYKEL LRVSYRTLST EDKKLIRKAF DVAVDAHKEQ RRKSGEAYIF
HPIAVAKIVA QEIGLDATSI AAALLHDVVE DNEDYTVQDI ERLFGETVAK IVDGLTKIST
FNADMDVSMQ AENFRKMLLT LNDDVRVIII KIADRLHNMQ TMESMRADKQ VKIASETLYI
YAPLAHRIGL YNIKSELEDL GLKYTEPEVY NDILLKMKES KEEQDLYIQE FTEVIKNSLD
KENLNYDIKG RPKSIFSIRR KMINQGVSYD EVYDKFAVRI IYKTDAANEK FLAWKIYSIV
TDHFRPNPTR LRDWISSPKS TGYEALHITV MGPKGRWVEV QIRSERMNEI AEKGYAAHYK
YKNKGEKSED NLDTWINKLQ EALENHGANA VDFVEQFKLN LYSKEIFVFT PQGDLKSLPK
GATPLDFAFS IHTEVGLKTR GAKVNGKLVP LSHQLKSGDQ VDILTSENAK PTPNWLDYAT
TARARSKIKN ALKESTKIVA EEGKEILRRK LKQLKITLNE DSVNEMVNHF KLKTSLDLFY
RVGTGTIDNT MLKEYASSRS NAFVSYLKNK ITRKPSINKE ELDKEEITNK YDLLVFGKEE
EKLDYKLAVC CNPIPGDAVF GFLTIKEGIK VHKSNCPNAV SLQSNYAYRI LPAKWIDSTQ
QDFPAQIILS GIDNLGLVND ITKLISANMN VNMKSISFES NDGVFSGKIN VVVKNKNLLT
KLMDNLKKIN GIDKVKRV
//