ID A0A368P7W9_9FLAO Unreviewed; 870 AA.
AC A0A368P7W9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=DU428_01055 {ECO:0000313|EMBL:RCU58005.1};
OS Oceanihabitans sediminis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Oceanihabitans.
OX NCBI_TaxID=1812012 {ECO:0000313|EMBL:RCU58005.1, ECO:0000313|Proteomes:UP000252249};
RN [1] {ECO:0000313|EMBL:RCU58005.1, ECO:0000313|Proteomes:UP000252249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S9-10 {ECO:0000313|EMBL:RCU58005.1,
RC ECO:0000313|Proteomes:UP000252249};
RA Li C.-M.;
RT "Oceanihabitans testaceum sp. nov., isolated from marine sediment.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCU58005.1}.
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DR EMBL; QPIG01000001; RCU58005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368P7W9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000252249; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000252249}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 870 AA; 98359 MW; F6556083DB4EFEA9 CRC64;
MAKKAKKETP LMKQYNAIKA KYPDALLLFR VGDFYETFGE DAIKTAGILG IILTKRGAGS
DNEIELAGFP HHSLNTYLPK LVKAGERVAI CDQLEDPKQT KTIVKRGVTE LVTPGVALND
EVLVSKSNNF LCSVYFEKNK IGISFLDVST GEFLTSQGNA EYIDKLLQNF SPSEVLVSKQ
KRTLFNDTFS TDYHTFYLED WVYQTDYANE TLTKHFNTKT LKGFGIADLH EGIIASGSIL
HYLGETQHNK LQHITSIARI AEDDYVWMDR FTIRNLELYH STNNNAVTLL QVIDKTISAM
GGRLLKRWLA LPLKNAEKIK QRHEVVDFFT KNKTTLQKTQ NHIKHIGDIE RLISKVATGK
VNPREVIQLK NSLEAIIPIK ALSSNCDNES LKIIGDKLQS CDVLRKKIKG MLNEDAPVNV
LKGNTIATGF SEELDELRAL STSGKDYLDK MLERESERTG ITSLKIASNN VFGYYIEVRN
THKDKVPAEW IRKQTLVNAE RYITEELKEY ESKILGAEER ILTIEQKLFA DLVVWMNQYI
KPVQQNAYLV GQLDCLAGFA QLAKDNKYVY PVIDDTHDLE VKDGRHPVIE KQLPIGEPYI
TNDVFLDRDG QQIIMITGPN MSGKSAILRQ TALIVLLAQM GSFVPAKAAR IGLVDKIFTR
VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGIS IAWAISEYLH
EHPAKPKTLF ATHYHELNEM TETFKRIKNY NVSVKELKDN VLFLRKLVEG GSEHSFGIHV
AKMAGMPQQV LHRANKILKK LERSHSSEEL TDKVKSIKDE MQLSFFNLDD PLLQEIKEEI
LHTDIDTLTP VEALMKLNEI KRMLVKKKGN
//
