ID A0A368QL82_SETIT Unreviewed; 2082 AA.
AC A0A368QL82;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Helicase and polymerase-containing protein TEBICHI {ECO:0008006|Google:ProtNLM};
GN ORFNames=SETIT_3G311900v2 {ECO:0000313|EMBL:RCV18574.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV18574.1};
RN [1] {ECO:0000313|EMBL:RCV18574.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV18574.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV18574.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV18574.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM003530; RCV18574.1; -; Genomic_DNA.
DR RefSeq; XP_004962606.1; XM_004962549.1.
DR RefSeq; XP_004962607.1; XM_004962550.1.
DR RefSeq; XP_004962608.1; XM_004962551.1.
DR RefSeq; XP_004962609.1; XM_004962552.1.
DR STRING; 4555.A0A368QL82; -.
DR GeneID; 101767169; -.
DR KEGG; sita:101767169; -.
DR OrthoDB; 208079at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR CDD; cd08638; DNA_pol_A_theta; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 504..695
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 732..932
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2082 AA; 228711 MW; 4CAB5B986AD8ED79 CRC64;
MASGSSRPQI DQFFPAKKRR PSSRKDDPPR LGSQHGSPGG AKGSLEGYLV RSPSTRATVA
ASAAPAGSPR GGDAGARRSL SAAMDVDVAS SATAAGDGAD LELKRFTTDF LSHCCSAIPP
MRDDSGYGEQ LEKKQRRSAS QSFLVPCDNA SAKKQCIVHC GGLEALKESD DNVAFKKQCI
NHHVGSEAVE ESVEGVKVSC MGFSALQRCS FTPNTTQHCK VGFSLAPGET PKSVSRNSLT
SPGEEFWNAA IELADGISAR ADKVRGRPEF DAAEDKSSCA VAVSSKTLPR SGKDELACQN
TVGSTDTHQM EKLSNKVDLL VANSQHIDSS PLPVKHLDFF HMDDIQVSGS KCEEKGSNEA
GNVQTNHVQL KESGLQRKEN LIDPGNEMKT GVLDLQTDSD SAAMIQCQGV FKSTTEGKLH
SIQEGDKDSH QKKSLAAYSN GCKPKKDSKS KFVSQEVEAS TPTSSVPLKD HSKLSSWLPP
ELCAVYMKKG ISELYPWQVE CLLVDGVLEK RNLVYCASTS AGKSFVAEVL MLRRILSSGN
MAILVLPYVS ICAEKAEHLE QLLEPLGRHV RSFYGNQGGG SLPKDTAVAV CTIEKANSLV
NKLLEDGRLS ELGVIVIDEL HMVGDQHRGY LLELMLTKLR YAAGEGNSES SSGETSGSSS
GKMSTHGLQI IGMSATMPNV AAVADWLQAA LYQTDFRPVP LEEFIKVGNQ IFDKAMNVVR
ILPKVADLGG KDPDHIVEMC NEVVLQGHSV LLFCSSRKGC ESTARHVAKF LKITSVGPSD
VSSEFSDAAS AIDALRRCPS GLDPVLEETL PFGVAYHHAG LTVEEREIVE SCYRKGLVRV
LTATSTLAAG VNLPARRVIF RQPKIGRDFI DGTRYRQMSG RAGRTGIDTK GESILVCKPE
EVKRITGIIR SNCPPLESCL SEDKNGMTHA IMEVVAGGIV QTANDINRYV RCTLLNSTKP
FDDVVKSAQD SLRWLCHKRF LEWNNETKIY SSTPLGRAAF GSSLNPEESL VVLDDLSRAR
EGFVLASDLH LVYLVTPINV DLEPDWELYY ERFMQLSSLE QSVGNRVGVI EPFLMHMAHG
AAMPVRGMPQ GNTGLRNKTP QAGGNSLINE QTLRVSKRFY VALMLSRLAQ EVPVADVCEA
FKVARGMIQA LQENAGRFAS MVSAFCQRLG WSDLEGLVAK FQNRVSFGVR AEIAELTSIP
FVKGSRARAL YKSGLRTPVA IAEASIPEIA KALFESSNWS GQDDSGLRRM QFGIAKKIKN
GARKIVLEEA EAARVAAFSA FKSLGVEVPQ FTAPSLPAIE DSPMRDTVVS PCGDQARSNK
VALGINAGDD KNKNNSSDYA APRISTYSLR EEHPGSYIQM KENLANNAKI TTQEAASPLS
TDFIAGSSST NLADKGPVNA YNFLGGFDCF LDQWSAVSEF CFDVHFIKKA MKPSSNLFEV
FGLAVCWENS PIYYCNFPKD LVTTGAKDSS EMWGNFQRRW KKIADIMQQK SVKKMTWNLK
VQIQALKSAY ISCQRLARFH LDHKVLENIE VLDNSYVLLS PISVYSGLDI CLMAWVLWPD
EESRTVPNLE KLVKRRLHSE GASAANRDGR WRNQMHKAAH NGCCRRAAQT KALYTVLNKL
LVSQNLYDLV HTIEGPLVNV LADMELWGIG ADMDACLRAR HIIIKKLKEL EKEAYRLAGK
SFSLNATADI ADILYTHLKL PVPKGCEKGK LHPSTDKQSL DHLRDQHPII PIIKEHRTLA
KLLNGTLGSI CSRAQLCTQS QRYIIHGNWL QTSTATGRLS MEEPNLQCVE HVVEFNTGKT
DKEYSSVSEV DHHQINAREF FIPTQENWLL VTADYSQIEL RLMAHFSKDP MLIELLSKPD
GDVFTMIASR WVGKEEALIS SKERENTKRF IYGILYGMGA NSLAEQLECS TEEAAQKIQS
FKRYFPGVSS WLHEAVASCR QKGYVETLMG RRRFLTKIMA GNGKEKAKAQ RQAVNSICQG
SAADIIKVAM IRVHSLITNR MKEDDSTDEV TRNFSEIGGK CHLILQVHDE LVLEVDPCMV
AQAGRLLQIC MEEAASLLVP LRAKIKVGKT WGSLEPFYPE PR
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