ID A0A368QP11_SETIT Unreviewed; 826 AA.
AC A0A368QP11;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SETIT_3G400800v2 {ECO:0000313|EMBL:RCV19623.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV19623.1};
RN [1] {ECO:0000313|EMBL:RCV19623.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV19623.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV19623.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV19623.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM003530; RCV19623.1; -; Genomic_DNA.
DR RefSeq; XP_004963277.1; XM_004963220.1.
DR AlphaFoldDB; A0A368QP11; -.
DR GeneID; 101766613; -.
DR OrthoDB; 399426at2759; -.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF906; NB-ARC DOMAIN CONTAINING PROTEIN, EXPRESSED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821}.
FT DOMAIN 12..97
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 191..421
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 826 AA; 93724 MW; 21974054B8CD46EA CRC64;
MEAAVVSASH GAMGSLLGKL GELLTAKYKL LKEAKGQIMF LKAELETMYV FLKKISDTEE
PDEQDKHWAK EVRELSYDID DSVSEFMLRV ECDSSKPHGF KGFIVRSMKL MTTVNTRHEI
AKEFEGLKNR VKEVSERRTR YKMDDVAPKS NNTAIDLRLL ALHAETASLV GVTGPRDQLI
QLMDAEGVSA HQLKVLSIVG FGGLGKTTLA NEIYRKLEEK FQCQAFVSVS QKPNIRKILR
TILSQVGFVP PKDTNIEMWE EPELISSVKK FLLDKRYLIV IDDIWDASAW YVIRCALPES
MNGSRVITTT RIEAVARACS TNHIECVYKM KALSDQDSKR LFFKRIFGLE DACPSYLKEV
SGEIVKKCGG LPLAIITISS LLANQSNKLK ENWDYVRNSL GSNFEPSLEG MRQILSLSYT
NLPYHLKACM LYLGIYPEDY TINKNDLARQ WVAEGFIYKA SATDPEDIAK NYFNDLVNRS
MIQPADTDYN GEVISCKVHD MVLDLILHKS REENFVTVID DIQDMTGHKD KIRRLSFNQD
SVIDSRFMGS VQLSQTRTLA RFGSSSRLPP FLQFKHLRVL IIETSRAIGP SPLLDFDRIC
HLFQLRCLKI VAEDYDAVLP SKIGDLQQLE TFEVQLDYKF LQGRKSLKLP SDIVHLSRLL
HLIVPVRTIL PDGIGNMRSL HTVHRFNLAN SLHSIKSLRE LTNLTDLEIG FAGSIIDHEV
VERGREVLHI CFEKLCNLKY LKVNIFPSEA YLDAFSPIPA SFRHLQRFHG SSFSRVPGWI
GELHSIYDLV LTVQEVLEDD VGILAQLPSL IHLILHIRGA PKGYHT
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