ID A0A368R3Z4_SETIT Unreviewed; 2864 AA.
AC A0A368R3Z4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SETIT_5G071600v2 {ECO:0000313|EMBL:RCV24270.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV24270.1};
RN [1] {ECO:0000313|EMBL:RCV24270.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV24270.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV24270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV24270.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM003532; RCV24270.1; -; Genomic_DNA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1744..2402
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2508..2820
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2832..2864
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2864 AA; 322834 MW; CC7E5721F2D5DD88 CRC64;
MILRQLLAVK EYRYQMKPRT YSSFVALYMK KVATVFNAKF SNQASSKDES FRCTLTLHVL
LENPPGDYPD IMREEVINGF CAIFSHIREE EGKLTRKLME CINTFLLKDG PNLGYKSVEI
HHVVQEFIFH CWPATLDQAL KSLFITYAKV QLKLARAIPE ILEKLVDIII KELDKNVNTG
PGFLWCEAPR DEKAGSLRCF QEECMDLSAT VFYLAHKCTL KTQNREKRLK TEHIMNLIVD
GLLKGSLFWS GSVCFLIHKY GYRVEKSLLI SWFEASCKAL RSVLSHANAI KFQDSILWLL
RALKEFSMVL MFNPREESQF CLTKSEMSIV ESCWQDIWNS LIHALPVFSS TALVADSALI
LLGGMIVRDQ VHTSFLSEDT WNLQIFKQMP SPSALYFIAC YFSRIGFQGD LSNSIFIRKS
LLRSTLELVH SKEFSLLNEQ NVVLIPEAIF SLCAAFSSLP INSSDTLQLF GDCKIYSKSL
EDESWVLKDE LLYSVEALSE ITLDSSAKVI SDKCHRVHLP GTIQQPMLLE LMDFIKGFVA
SNEQFEKLDL PNLVFVCSLL CNLVHRALLS RAMGDKSSLM QEVLNYITNI LKHIVSFVMK
RNNELSHGLT NLSLPLDTTG SALSSFKSFL SSPLFNLSRV DNRVSSVVIK GVTELLDELL
VAISQLFSQL SSLVNSFDGE NAGKVLPISC VNSQDLNPIV DCKSSVADMD LDVMDSGEVD
SVTTSGSGNM GSFLRPLEWK LELVSIISTF FSVSSLHTWE ILYNLVEKES DVKVCQVILL
NLCRNISASS KTVSSMVHLI NDTRDRCTSS LLNSTGCLAY VHALLRTLVA LRNSGQNTDG
KQQGCKGIFS ENEDVLLDLV NKATEISSAD WFSRIKLIDC ISSFICLFPD VAQDLIGCLL
DMLHDTDYRV RLYLAREIVV LFQTWEGHNE LFYDVRSTIG AKMVAFSINS PVTAREVLAV
GPQSVLVIET ALITLAHLSV HSEDVEVECV FMISAAAAIE PSQRELAYAL FDSISKSLGY
ASRSKYLDQV MGPILFRWVA CEMSLVSLVE VQEMFGYGSA EPKNFVEHCS LWLLPFLILR
GDAADLNWIS KILSQPLPVI IKRYFVPIFG LSIAARCGTG PEKDLAETAL CESLLQLGEI
SELERDDLIK KHMVSIVALL LSVSSSSHGS QIPYFSKEVV ALSVKTVVDG FVDTMDDDLA
HTVVIDKINI FRADRVFKFL LAIHQQVADA CHPRHMGNRL CAIEVLIDVL GHRVVRESTC
FYIICIVGNY IQQKPLQGQC CNILSKLLAY FDGNSSAETV EVLGRQLQVL VPKLITACLT
NEKEERSGIA DSSRVLSLLR QLTVDADPML YDYIRELEPL PCLDCLKDIR EFHTSLSASY
ASRDQFLKFV NRAPHLPPEL FLLSLRMYHN KLLLGEIISR SDLSAADTDI VNCWCSDPDV
VSAVWTLVDI CSSSPVANEA SPVVADFISR AGLSDAHQVI FHLPTLIRKH PVELHSGSAS
KDDKLCSDYG ISDDILVELL KLLKTYLSDE SVEIIDAASQ TLRGVLSTTK GLNALQSLDS
LDRSLLMVHS RGVNTQIVEQ IILGMEKYSG VSLEDSDMWQ TDGRTYEQWL CTLVSSLICH
CDDIILRLCR SLAFLKVKAA ELLFASTLLN IAGNVDSNAA ICRLISTKVE KIIFSDSNHS
LKSIHLFLDA LNVIRSFYVA EKARSCPSNT FQDGRSVRSK SRSPATTASS SWKKVYWLSV
DYLVAARAAS RCSCDFTALM YVELWCEEQF NRLAIGPPDF SHEESLPPHV GLLVAAFTRI
NEPDSIYGIT LANEITSQII RYEHEGDWSS ALEYYDLLVR STPKEHLGNL TGSVLTGSSA
SRAEDKMLNC KMHKGLMRSL QKTGCSHVLD VYCEGLTHLK GSLQQDAEFI DIQYEAAWRA
GNWDFSFFIP YSSRSSTRTQ SYCLFNENLH SCLRSLENGD SEEFHAKLCQ AKMDLVLALS
STSMESTKYI HSTILKLQML DHVTMVWDLR WSLCHNQTSE SLPGTKKFSP VSTIPTGMQL
ELLDKEWNFI VFQTEHNLDL FEPFLAFRRA LLKVLGCEEH LVTHLFQSAS ALRKGLRFSL
AAAALYELKE HCFHQDGGIM PNTYFLSRLE EAKLLRAQGQ HDMAISLGKY ILQKHSDKKD
VSDVYRLVGK WLAETRSSNS GTIIEDYLRP SMDLTEFKKS TDKRYMSRQC RTHFHMAHYT
YSLFKSYEER LSSNEWQAAL RLRKYKTREL ETLIKRLKSS SKGVKTDYSV KIQELRKQLA
LDREEAQKIQ DDRDNFLNLA LQGYQRSLVV GGKYDLQVVF RLVSLWFSLF SRDQVVKAMM
KTTKEVQSYK FIPLVYQIAS RLGSSNTQGS SNFQIALASL LKKMALDHPY HTIFQLLALA
NGDRVKDKQR SRSSFVVDME KKLAAENLLK ELSSCHGALI CQMKQMVEIY IKLAELETKK
EDTNKRIPLP REVRSISQLE LVPVVTATVP VDPSCQYEVG SFPHFSGLAD SIMIMNGINA
PKVIECFGSD GNKYRQLAKS GNDDLRQDAV MEQFFSLVNT FLQNHRDTSQ RRLRIRTYKV
VPFTPSAGVV EWVNGTVPLG EYLLGSTRIS GAHGRYGTGD WTYLQCREYL MSEKDKRRAF
LKICNNFRPV MHHFFLEKFL LPADWFQSRL AYTRSVAASS MVGYIVGLGD RHSMNILIDQ
DTAEVVHIDL GVAFEQGLML KTPERVPFRL TRDIIDGMGV TGVEGVFRRC CEKTLSVMRA
NKEALLTIIE VFVHDPLYKW ALSPLKALQR QKEIEDTDSC LDDSQEAYEG NKDAARAILR
VKQKLDGYED GEMRSVQGQV QQLIQDAVDV DRLCQMFPGW GPWL
//
