ID A0A368SF52_SETIT Unreviewed; 3508 AA.
AC A0A368SF52;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SETIT_9G099800v2 {ECO:0000313|EMBL:RCV40993.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV40993.1};
RN [1] {ECO:0000313|EMBL:RCV40993.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV40993.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV40993.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV40993.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CM003536; RCV40992.1; -; Genomic_DNA.
DR EMBL; CM003536; RCV40993.1; -; Genomic_DNA.
DR RefSeq; XP_012698161.1; XM_012842707.1.
DR STRING; 4555.A0A368SF52; -.
DR GeneID; 101758768; -.
DR KEGG; sita:101758768; -.
DR OrthoDB; 8448at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 948..1552
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1764..2108
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3476..3508
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3280..3317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3417..3440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3290..3306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3423..3440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3508 AA; 390212 MW; 8506682BC26899E6 CRC64;
MLIAAKFPHC FRPQFVDIMD LLLGWAFVPD LADADRSMIM DSFLQFQWHW LGNLQFSLGL
LPKFLADMEV LVHDPNLAAS HNSGRLRPLF ACFSTVLQIM ASGVAERNNL RELVAGPLEA
LAPQLLRCAS VIASKLGWSE RMEEASRCLV LLAEILQERF AEFYVLFVDV LAQSLEVASS
AQLVAALKTN LQVLSLQNLG LCASSVGALL DFSSILSKLR LHPNHTVVAN SAATYLFCLQ
HGSEDVVDQA IASLTKELEL IKSLLEEGQA SYPCIQSLSL ESNNERKSKL NSGAHSWAQY
SEDQLLSLMK FDLKILLATI ALDTRKRNER ASSLTSFISE KLDPFGTPFH NFLEMQFQIF
STLHKLSNME LSSIMATSEG CKTQLISCEC KKKFVHKYGK YIVQGLNASS SMTLKLEALD
WIASFENLIR GMERDVDKFS FSYEAIGDAT LSNGILFTVL DCAYDREPKV RCHVALTLEL
LFLGKLINPM NFLVVAQVLL DKLSDPDSNV KDAFLRLFSI ALPITTYAFG LLVDKHSYLN
SSDIANMSNH CMNWRHVLAV KQQPRKLHWQ QLVSILSYLS LRLKLPLSSW VQRLVFSYRG
KKDMLSGQTD MSGDADGNEL PKGPSVDRAI IDRIYSVNNH AAVWWGIHEA ARHCINLRLR
THLGGPTQTF AALERMLLDV TNVLTPEAKE GEGRYIGPAD ICLLPMRLLL DFVEALKKYA
YNAYEGSFVL SPPPKASSVF FRANKRVCEE WFSRICDPML NAGLAMHCSD AVVHYCSLRL
VDLRNLAASS LRGNSHTGGA TESHHGFRER LEADVLKVLR HVSLALCRCH ETDALVGLQK
WAVSTLYTYF EQDNQLVRSV SDCDKHFSWM SGLIYQSQGQ YEKAAAHYSH LLQSEEALTS
MKSDGIQYII ERVIECYTSL SDWKCLESWL AELQVLRAVH AGKPYSGALT SAGNELNAIH
AMACFDEGDF HSAWGYLDLT PKSSSELTLD PKVALERSEL MLLRGMLQSS SKLEGIKEEL
DKAKLMLDEA LSVVPLNGLP EAAACAGQLH CIFAFEEASG LTCQNGPNQS RSIMDSLLKV
LHDPIDRMHQ DCSMWLKVFK VYRNTQPSSL STLLLCQKLA SLARKQGNFM LATRLNQYLT
NHPLKSSDEM DKEILELNIK YEGALLKREK GNNEEALSEM WSLVRASVLS TINCSSDIGT
PHSLIARACL KLSTWIEQEN STPILNRIIP KVIEDLSDSN GFQNGTEELL FGDSVAVSTL
NYRALAEEII GTARKTSWQL CPSMGKAWLA YASWCFTHAS YSLSGKDSNL QNSLSPVLQS
ELSPDRYHLT NDEKSEVEEI IRSICADKHA DHVGCDYPVT AGPITSLIEQ AIHLIETAAG
APGFEAREGE DPPAVLASEL IVLLCKSDCA KDNTPLIDKL IEIWWSLRKR RVSLFGHAAH
AYFQYLSHSS TELQPSYHHD ALKGKTRSYT MRAMLYLLHI MLNYGVELKE TLESGVSTVP
LLPWQEIIPQ LFARLSSHPE KIVRELLESI LLKLGKLSPC SIVYPTLVDI NACEGEPSEE
LQHISDFLVK LYPNLIKDVK LAIEELGMIT VLWEEQWLST LQDLHSDVLR RINILKDEAA
RVAANSTLSS AEKNKINAAK YSAVMTPIIV ALERRLASTS REPKTSHEMW FHKEFNAKLK
SAITTLKTPP GSPTALGEIW QPFDSIAASL ATHQRKSCIL LSEIAPQLAV LSTSDIPMPG
FEKQILDSSE SFAGNHGIVT VSSFCKEVTI LSTKTRPKKL VLQGSDGQRY TYLLKGREDL
RLDSRIMQLL EAINSLLYSS SDTRSRNIAL RFYSVTPVSG RAGLIQWVEN VSSIYNVYKS
WQKRSQLAQA EAQLSSVSAG NIRNPVPPVP RPSDMFYGKI IPALKEKGIK RVVSRRDWPL
DVKRKVLLEL MNETPKQILW QEMWCASEGF RNFNSKVKRF SSSVAAMSMV GHMLGLGDRH
LDNILMDFSN GDVVHIDYNI CFDKGKRLKI PEIVPFRLTQ TIESALGLTG VEGVFRVTCE
EVMDVLLKNK DTILMLLEVF VWDPLIEWTR GNIQDEAGIA GEEKKGMELA VSLSLFSSRI
QEIRVPLQEH KDLFLTNLPA TVSALKKFLD TLDHYEVASA MFYHAEKERS NVLQNEMSAN
SILADATTVA EKSRTSFEIH AHELAEAKAA AVDEANKLKI WVEKYARVLE AIRDRSIVCA
ESCMQLNCKD EALSLISAVL ESGVPLTVVP EPTRAQCSEL DREVSQLISE LQGGLSSALD
SLVEYSLVLQ QVLPVNYITT SPISSWAQVL QLSVRNTSQD MLSLAKRQAA EVIAKVQGEG
THLVQQRYRD LLNQMESYIT CVERLARECS ELMNSIGLDN EMQSKERILS AFMNSIQLPS
QKNDGDDTHL SHSESLRQGE IKIPAKGDIQ ETTSKVLSIL GIAVGQLYSD IRAKVSDLST
KAIGKAKFRA DDSGLQADAG MGLQFFEQHI EKCALISSVV DEVHEVIGKT LAETSVAYAK
PHPRHWASTF QAALHSSINM IEQMTEAFLP EFIRSFVSHN SEVMEAVGLI SKIRGSVDKA
LEKLVEVELE RTSLTELEQS YSVKVGRITE QQIALEEAAA RGREHLSWEE AEELASQEEI
CRAQLEQLHE TWSQKDLRIS SLMKVEDSVI NSLLSSKQYF SSLVDRDQES EFHFRQSKAL
LSILAKPFAD LELLDRVCPS NIDRPISSMK DALSLGSSLS DVVWPLAGIW KDHAFFVWEL
SLLDSILDLC MHEMSSSVEH SINANQLYLT LKKKLAIHVE KQVFRYITER IAPSLILSLD
EEISALLQLG QGRRESDQPK RDFAAVGRVA LMLEEYCNAH ETARTTRTAV SLMKKQLNEL
TEALRKTILE TVQVEWLHDL SSPHVQKAKV LSQNILSDDK FISLILNLSR SNMLDKIQSS
VSLITRSIEF LQACESISIS AEGQLERAMG WACAGTNTSG AGGSTAKGSG IPPEFHGHLL
KRRKLLQVVQ KEASDLVKLC TSVLEFEASR DGLYFIPEDK APEQSMDKGR AWQQTFVNLL
TRLDAAYHSF ICAEQEWKVG QVNLETAGKG LFSANNQVSV VSVKAKSALV NLQDALVAMY
EHACEVSALL SGFKHVSQDR TALTSECGSL LDEVLAIADG LHDVYALGKE AAAVHSSLMT
NLSKANATLF PLEACLSADV TIMSEAISKE REKNNASMPL IHGKALFQSY NIKIREACKN
IEPLVGPLTE NVEGLYSVVM KLGQLSSLHA ANLHKALEVP GERESVRSQD IPSTDLLQSD
SSTEKDRGSS GSVECESADL EMNTAVSLQD GCWISPPEHS YTSSSGCTTG LTQISSSDNL
EKIDALMDVR AEIEGPGATD QETRDSSDNQ SISSNVALTH ASNIHEVETH LVEGRIESED
SSAASKQVRG QECNNSDPKS YADSLIRVTR GKNPFALSIL KQVEHKLHGK DIDGTRSLNI
SEQVDYLLKQ ATSIDNLCNM YEGWTPWI
//
