ID A0A368T3Z6_9ACTN Unreviewed; 548 AA.
AC A0A368T3Z6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=DEF24_15315 {ECO:0000313|EMBL:RCV57410.1};
OS Marinitenerispora sediminis.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Marinitenerispora.
OX NCBI_TaxID=1931232 {ECO:0000313|EMBL:RCV57410.1, ECO:0000313|Proteomes:UP000253318};
RN [1] {ECO:0000313|EMBL:RCV57410.1, ECO:0000313|Proteomes:UP000253318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TPS81 {ECO:0000313|EMBL:RCV57410.1,
RC ECO:0000313|Proteomes:UP000253318};
RA Ng Z.Y., Tan G.Y.A.;
RT "Novel actinobacteria from marine sediment.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCV57410.1}.
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DR EMBL; QEIN01000112; RCV57410.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368T3Z6; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000253318; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:RCV57410.1};
KW Helicase {ECO:0000313|EMBL:RCV57410.1};
KW Hydrolase {ECO:0000313|EMBL:RCV57410.1};
KW Nucleotide-binding {ECO:0000313|EMBL:RCV57410.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000253318}.
FT DOMAIN 188..342
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..548
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 548 AA; 60909 MW; 1B98EA1B2FBCD7E9 CRC64;
MSCLIVQSDK TLLLEVDHEL ADDCRRAIAP FAELERAPEH VHTYRVTPLA LWNARAAGHD
AEQVVDALLA YSRYPVPHAL LVDVAETMGR FGRLRLLSHP AHGLVLQALD QAVLEEVVRS
RKVRPMLGER VEPDTVAVHP SERGNLKQAL LKLGWPAEDL AGYVDGEAHP IDLVESDWKL
RDYQREAADG FHAGGSGVVV LPCGAGKTIV GAAAMARTRA TTLILVTNTV SVHQWRSELL
RRTSLTEDEI GEYSGTRKEI RPVTIATYQV MAARRKGAYA HLELFDARDW GLIIYDEVHL
LPAPIFRMTA DLQARRRLGL TATLVREDGR EGDVFSLIGP KRYDAPWKEM ENQGWIAPAD
CVEVRVTLTD AERLAYATAE PEDRYRFCSS TPAKTAVVRE LVRRHDGEQI LVIGSYIDQL
DELGAALDAP VLKGETRVKE RERLFDAFRS GELRTLVVSK VANFSIDLPE AGVAVQVSGS
FGSRQEEAQR LGRVLRPKSD GRSARFYAVV ARDTLDQEYA AHRQRFLAEQ GYGYRIVDAG
DVLAGDEL
//
