ID A0A368XEG3_9BACI Unreviewed; 782 AA.
AC A0A368XEG3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
GN ORFNames=DFR57_10969 {ECO:0000313|EMBL:RCW66352.1};
OS Saliterribacillus persicus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Saliterribacillus.
OX NCBI_TaxID=930114 {ECO:0000313|EMBL:RCW66352.1, ECO:0000313|Proteomes:UP000252585};
RN [1] {ECO:0000313|EMBL:RCW66352.1, ECO:0000313|Proteomes:UP000252585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27696 {ECO:0000313|EMBL:RCW66352.1,
RC ECO:0000313|Proteomes:UP000252585};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RCW66352.1}.
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DR EMBL; QPJJ01000009; RCW66352.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A368XEG3; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000252585; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378:SF1; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Reference proteome {ECO:0000313|Proteomes:UP000252585}.
FT DOMAIN 707..782
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT COILED 226..261
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 533..600
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 331..338
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 782 AA; 87837 MW; BE13F93239E1A434 CRC64;
MNERIFKVLE FDKIIQRLNQ LTASSLGEEK TRRLKPLTDL NEVEKNHLET DEAVSVLRLK
GHIPLGGIVD IKPMIKRAVI GGILNANECL DVAGTIYGGR QLKLFIEQME EPELPIIREM
IDAIVTLPEL ERMIKNAIDD HGHVMDGASD QLRSLRSRIR SNQSRIRDRM DNITKSKSKM
LSDTIVTIRN DRFVLPVKQE YRMAIGGIVH DQSASGQTLF MEPQAVVELN NELQSLRVKE
KQEVEKILRD LTIAIAEQEE QLSSNVEILG SVDFIFARGK LSEQMKARKP KMNDQGIIKM
MQARHPLLNE DEVVANDIEL GESYTSIVIT GPNTGGKTVT LKMVGLCTLM AQSGLQIPAQ
DGCQLSLFNE VYADIGDEQS IEQSLSTFSS HMTNIVKILK EVDEKTLVLF DELGAGTDPQ
EGAALAMSIL DYVVDKKARV IATTHYPELK AYGYNRENVV NASVEFDIQT LKPTYRLLIG
VPGRSNAFEI SRRLGLDEAV IAQAKMQVGT DSKDVENMIA SLEASRRGAD NDYVEAHQIL
EEAEYLRNEL KDQLDKLDQK KEMVLKKAEE KAEKALAKAK EEAEQIVNEL KSRKEDINFK
DHEWIETKKL LEESQPKLTK KTPDKAETAP TPKTKELKVG DEVKLLSLDQ KATILEKTGK
NEFQIQVGIM KMKAKRKDLL FLNRTQDKIE QPLTTMRGQA YHVKPELDLR GERYEDALQQ
LEKYIDDAIL ANYTTVSIIH GKGTGALRQG VKTFARKHSR INAAKDGGMN EGGSGVTVLE
LK
//
