ID   A0A369B7W8_9FIRM        Unreviewed;       728 AA.
AC   A0A369B7W8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=DNA gyrase subunit A {ECO:0000313|EMBL:RCX17622.1};
GN   ORFNames=DFR58_107169 {ECO:0000313|EMBL:RCX17622.1};
OS   Anaerobacterium chartisolvens.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Anaerobacterium.
OX   NCBI_TaxID=1297424 {ECO:0000313|EMBL:RCX17622.1, ECO:0000313|Proteomes:UP000253034};
RN   [1] {ECO:0000313|EMBL:RCX17622.1, ECO:0000313|Proteomes:UP000253034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27016 {ECO:0000313|EMBL:RCX17622.1,
RC   ECO:0000313|Proteomes:UP000253034};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RCX17622.1}.
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DR   EMBL; QPJT01000007; RCX17622.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A369B7W8; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000253034; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000253034};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          9..457
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   728 AA;  82343 MW;  AB86E5F55817A507 CRC64;
     MANNNTVEQK IVDTLEQNYM PYAMSVIVSR AIPEIDGFKP SHRKLLYTMY KMGLLTGAKT
     KSANVVGQTM KLNPHGDSAI YETLVRLTKG NGALLHPFID SKGNFGKQHS KDMQFAAARY
     TEVKLDKLCE EIFKDLDKNT VPFIDNYDGT MKEPRLLPTT FPNILVNSNQ GIAVGMASNI
     CSFNLREVCE ATVEYLKDEN ADILKHIKAP DLSSGGQLIY NEREIRDIYN TGRGGFKVRG
     RYRYDSSNNC IEIYEIPYST TTEAIIEAII ALVKDGKIRD ITDVRDETDL SGLRITIDIK
     KNTDAEALMN KLFKLTPLQD SFSCNFNILV NGTPRVMGIK TILKEWSVFR TECIKNQILF
     DIDKKSEKLH LLLGLRKILL DIDKAIRIIR DTEREADVVP NLMKGFGIDQ VQAEYIAEIR
     LRNLNKEYIL NRVSEVDSLQ KEIQDLKDTY GDDRKIKRII IKQLNDVSAK HGQPRKTEII
     SVENIEEITT EHLIEDYRLK LFLTQQGYLK KIPLVSLRSG PEQKLKDDDS IAQEVEARNK
     ADLLLFSNKC TVYKLKIYEI NDCKASSLGE YLSNLLGLEQ GERVISIVVA DDYKGHVLFC
     FENGKMAKID LSSYATKTNR KKLANAYSDI SPLVSMMYID EDVELAAFSS IDKVLVFNTA
     GINSKSTRDS QGVQVLKSKK GSVVTAVKPL GEAALTDADY YRTQNIPAVG CYLKDEDKQD
     NQLRLKLE
//