ID A0A369J5T8_HYPMA Unreviewed; 767 AA.
AC A0A369J5T8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE SubName: Full=AMSH-like protease sst2 {ECO:0000313|EMBL:RDB17318.1};
GN Name=sst2 {ECO:0000313|EMBL:RDB17318.1};
GN ORFNames=Hypma_001899 {ECO:0000313|EMBL:RDB17318.1};
OS Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB17318.1, ECO:0000313|Proteomes:UP000076154};
RN [1] {ECO:0000313|EMBL:RDB17318.1, ECO:0000313|Proteomes:UP000076154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=51987-8 {ECO:0000313|EMBL:RDB17318.1,
RC ECO:0000313|Proteomes:UP000076154};
RA Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA Jeong J., Song E.-S.;
RT "Whole genome sequencing of Hypsizygus marmoreus.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDB17318.1}.
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DR EMBL; LUEZ02000113; RDB17318.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369J5T8; -.
DR STRING; 39966.A0A369J5T8; -.
DR InParanoid; A0A369J5T8; -.
DR OrthoDB; 5490729at2759; -.
DR Proteomes; UP000076154; Unassembled WGS sequence.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF13; FI19924P1; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RDB17318.1};
KW Protease {ECO:0000313|EMBL:RDB17318.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076154};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 593..723
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 149..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..469
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..568
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 86579 MW; 65D224CFA1F4C251 CRC64;
MNSPYSSSSR PNPQTRPAMI AELAEAALEN LWDEKLELKH YLRTAERCRS HAKHFINEDD
YENAFIEYAR AATLVLEKLS SHRDYHTLLN AAQRHNLALN GQDILDKLGE LKPMLVDRYE
KWSKQHPDPT NPNILPDFRR RRLRSEELFA QEEQRRRRSR HDRPRTRERD RDKDKVGLER
EREKQSAVEE QLAEELRLYK EQREAVQRQQ AADDRERERD RAASRAAVAA ADRKREVAVA
AARSAATQPP GAVPDLTFSR TPVQNNAYNG TPLPQDSRRP DEEHFRHQQQ QEEMRHREEE
IVRKREQKKW EQEGFARRQQ ESDEAARAVR QTIASNNMGV ATAMTPSSLA STPSVTYSTS
ASSSNVSTPA TSFYENMTPT QSTSGLRPPP AVKSRPPSFL SAQFEHVPPI MPLESPTRYE
DDSTDSESVH NGRRSSGKQK QAMDYSNRTP SRAPARSPSY PPPITTTSPP PADTRIQYPQ
LMSQHQKHQG YYPSLNSMFG PATADSFRYA TAAPGSNFKD MYPSYLLPRP SAPYGTPQPS
PTPQAHPIQY PSYPGPSRPA PPVPSTTPPS SARASIDRTM GVPKSEPSPA LRTVTLPRGC
LPRFLTLAKA NTDMNMETCG LLLGRDRGGK FLVTTLLIPK QHSTSDTCTM DEEELVMQFT
EERDLITLGW IHTHPSQSCF MSSVDLHTHS GFQCMLPESF AVVCAPKSNP NFGIFRLTDP
PGLKTVLECT AKEAFHPHPD LPIYTDADKG HVQMKEIPLE IVDLRNR
//
