ID A0A369J6N8_HYPMA Unreviewed; 605 AA.
AC A0A369J6N8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Nuclear fusion protein KAR5 {ECO:0000313|EMBL:RDB16075.1};
GN Name=KAR5 {ECO:0000313|EMBL:RDB16075.1};
GN ORFNames=Hypma_003435 {ECO:0000313|EMBL:RDB16075.1};
OS Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB16075.1, ECO:0000313|Proteomes:UP000076154};
RN [1] {ECO:0000313|EMBL:RDB16075.1, ECO:0000313|Proteomes:UP000076154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=51987-8 {ECO:0000313|EMBL:RDB16075.1,
RC ECO:0000313|Proteomes:UP000076154};
RA Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA Jeong J., Song E.-S.;
RT "Whole genome sequencing of Hypsizygus marmoreus.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDB16075.1}.
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DR EMBL; LUEZ02000136; RDB16075.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369J6N8; -.
DR InParanoid; A0A369J6N8; -.
DR OrthoDB; 1406522at2759; -.
DR Proteomes; UP000076154; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000076154};
KW Signal {ECO:0000256|RuleBase:RU368082, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..605
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017083251"
SQ SEQUENCE 605 AA; 66587 MW; 608C4CCC6D108132 CRC64;
MLLTFMACIL LAQLPPWCFA MLWSRGHSAV STTPGKIGAS AETADTLLSG DEIITMISGQ
DSLDHYTQRP DCFRRAAGLI RARCEQLDMY EEERVKASAA ISMTLCELAT AKHHSIPLEC
VPFSLDSGAD GDASISQAQG QCVDALSRSA QFWSSYSGYL REVTQLCFAL RRWNDMDMAR
DLYRNATLEQ STLLRFLVAR EKASNATNQA LDARLTELQN TVSQMVLTAG NLESSTSQFD
SWLQKEFRNS LSTFAAMSLD IQSRQEEHAS HLLSQTSAAL DKVARQHAYE LQMAAFPLLE
ESLTAHVDTM LMYFHAQVRT SLNITREVED RWISFGNGLD GLTQSIVRLS ATATEVSHIF
ETSMDQAQAL HQKQHLATAS ASHLVDVLAN LTTTTHEEFD KITNASTVLI QQTLLHANSG
ASSWLVLGLT RMMEVILRVD PQSLEYFNHL PNFGVLVTFL SLMGSFVRVA ASSITSSSLL
GNTLRGLSVP GLRICLHKRQ TFNTLSLALP VKAPPQPTEA AHQILAFAGG SSSRDTARVL
AFLVSRNTFI AQIIDLLSSD HALSLTCCIA RFLVVTVRLP VVVGDFSLRL MMLSFRVIKP
GITET
//
