ID A0A369JDS4_HYPMA Unreviewed; 658 AA.
AC A0A369JDS4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN Name=SPBC4B4.04 {ECO:0000313|EMBL:RDB19482.1};
GN ORFNames=Hypma_013626 {ECO:0000313|EMBL:RDB19482.1};
OS Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB19482.1, ECO:0000313|Proteomes:UP000076154};
RN [1] {ECO:0000313|EMBL:RDB19482.1, ECO:0000313|Proteomes:UP000076154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=51987-8 {ECO:0000313|EMBL:RDB19482.1,
RC ECO:0000313|Proteomes:UP000076154};
RA Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA Jeong J., Song E.-S.;
RT "Whole genome sequencing of Hypsizygus marmoreus.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDB19482.1}.
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DR EMBL; LUEZ02000080; RDB19482.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A369JDS4; -.
DR STRING; 39966.A0A369JDS4; -.
DR InParanoid; A0A369JDS4; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000076154; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000076154};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 213..406
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 466..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 606..633
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 539..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 70855 MW; 36F6411327C30490 CRC64;
MASQISQQYA FRAQKSLGLV NGTPNYDLVP GFVAPDVPAR TFQYSADGRL YAYALPTVVR
IYQAEGAQLL LELAISNIVD IRFSPRGTYL STWERPVKLE DGSQHKNLRV FSASTGEELI
AFSQKSLDGW DLQYTISESH AIRLVSSEIQ VYRPAEWSKG IVDKLKVEGA SSVSLSPGLN
PSVAVFVGEK KGAPASVKIY GLLTLAGPPT CQKSFFKADR AQIKWNTLGT QVLVMTQTEV
DNTNKNYYGE TGMYLLSAAG NFDCRVTLDK EGPIHDFAWS PNSKEFGVVY GYVPAKTVLF
DQRVRTLHDF GSATYNTISF NPQGRLLLLA GFGNLAGKID IIDRRTLRKV CTIDAPNTSY
CEWSPDGRFI LTATLSPRLR VDNGVKIWHC SGALLHNQVA EELYQVAWRP TPVESVPPFG
HHVPPAPAPS ESVKNLAAIQ KPVATKAAGA YRPPGARGLA TPAIFKREDE GGAPRVPTNG
TSTPPRVYNR SPNPPGAAPN GQYNGGGGGG YGMNGPGQGQ QGGGRRQVPG APHTPSPGPE
GEKKNRKRKV KKEGGEGGKG GEEGPAPLEI AVNGLGKTAI AEPQEPLVVE AVSPITPGPD
SSLDPVAKKV RNLSKKLKAI DELKEKAKRG ERLEATQLRK IDGEAEIRKE LTSLGVTS
//