ID A0A369JJ64_HYPMA Unreviewed; 3152 AA.
AC A0A369JJ64;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=Hypma_012444 {ECO:0000313|EMBL:RDB20445.1};
OS Hypsizygus marmoreus (White beech mushroom) (Agaricus marmoreus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae; Hypsizygus.
OX NCBI_TaxID=39966 {ECO:0000313|EMBL:RDB20445.1, ECO:0000313|Proteomes:UP000076154};
RN [1] {ECO:0000313|EMBL:RDB20445.1, ECO:0000313|Proteomes:UP000076154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=51987-8 {ECO:0000313|EMBL:RDB20445.1,
RC ECO:0000313|Proteomes:UP000076154};
RA Choi I.-G., Min B., Kim J.-G., Kim S., Oh Y.-L., Kong W.-S., Park H.,
RA Jeong J., Song E.-S.;
RT "Whole genome sequencing of Hypsizygus marmoreus.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDB20445.1}.
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DR EMBL; LUEZ02000062; RDB20445.1; -; Genomic_DNA.
DR STRING; 39966.A0A369JJ64; -.
DR InParanoid; A0A369JJ64; -.
DR OrthoDB; 1649925at2759; -.
DR Proteomes; UP000076154; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR046700; DUF6570.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF5; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF20209; DUF6570; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000076154}.
FT DOMAIN 623..766
FT /note="DUF6570"
FT /evidence="ECO:0000259|Pfam:PF20209"
FT DOMAIN 897..1123
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT REGION 1384..1417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2313..2342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2401..2450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2468..2495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2752..2816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2907..2984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2318..2335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2401..2420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2432..2450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2468..2489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2758..2776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2915..2936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2939..2960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3152 AA; 351766 MW; FCA388FEAF8B4359 CRC64;
MNARRVTSCG LWSRPMDSIW PRHPSCDYGF ISWGLPFFLS ASPLFFFFLY SAFFCLCFLS
MTAFLNGRSV SVSYDVSLAT STVSSPNFCQ NASSLVSVNT PHGVFTCSLN FAVASGSPSD
VVLGLDWSAF YREYLINEGV HVMQSVPSTY LRRYSSSPVH EPDLMHTSQL LPSPSCQRPQ
SCVPSSMNSA LSASLSENHT IINNLNASCS GSFHGPNFDI LKKLLLDNDS VIYSTAYGLY
DLLESHGISC QGLTVHAAQQ SLLHHLIGGL CACSSSRACR AVAGSLTVVE LNYMICSELI
DSASALSLVQ SKAICHGLGF SFDVGSDEHH LQQVVDSLTA WREFSASSSS QSLHSSVEAL
SRLSKPRLLS LAAAHGLSLF GTRDDLRLAI VQHIFSANCF ATASITRPPA CLDMEDSVPY
SNMEDEHKLR LLQQLSPHIR LTSLRRVFKA NDIPFTMDMS LGQLKRSLKR FLASKTRGKS
TPTFVSEQLS WPQLVPTSVK EKVQNMFLDA TSSERLAHGT CASCAEDCLL SDCQRFPLSA
IDVTLLRRPD YDFLFSNDFA PGEDNEMDSP RWLHPHTVPP NMPYSEGPLA HVLLDKAGVE
DRTGCSDDIS LRLCDDCSSS LLRGKTPALS IANRNLLGEL PPELQDLTPI EESMIARCRA
QCWIVQLKDE DSDTSVPNAQ RGMRGHVIIY PQDPSVVAEI LPPKIEDILA PICVLFVGSA
PPSEEWLRTK AKPLAVRANK IRQALIWLKA HNYLYSHIVI DHDRINALPE NGILPFHVEH
VLPSHAQDSV TSRYDGSELE ADISDRNRSV SNDDMIFHNV VIADVNGHAS SNELRAAAVR
HVKKGKGYVE LPRGCQPANE FHNPQLFPKM YPTLFPYGIG GFEDSKRASP ISLKRHVKHL
LALADRRFQV HNSFMFTAFN ILQRRAVLLH TSIRVKRARF NSVANSLASV SAEAIHIVAE
RVSRGDLKTA NSDEERQVLR LMQEVRVVNS HVPGSSSART AMRNEIRALT MSKGSPSFYL
TVNPADVYNP IVKFLAGAEI NIDQLLPEQV PNYWEQSLLV AKNPVVAAKF FNIYMKAFIS
TLLGVDPSCP TENGTSGVFG IVNGYYGCVE AQGRGTLHCH MLVWLKGSLN PDVLKKTALE
NEDFKARLVS FLEDSIASSV PDELVPDVDL PTSSNHPCSE RMSTNANPHI RRKHLRILVE
RCQRHKHNDT CWKYWKGPPH PKECRFDLDP KKIQPTTTID PETGEIDLRR LDGMVNNFNA
TIIECIRCNM DIKFIGSGAS AKAIVYYITD YISKSQLKTH VAYAALELAI QKLGAFNPLD
DEKTCRAKRM LQKCAHAMIS HQELSAQQVA SYLMDFEDHF TSHEYRRLYW TAFEAFINKQ
DPSPECYSTD APSPASDDSS AQTAPEIPDN DTELEDVPTP IDDVEEASNE HASNDEQLDE
ISISIDENGE VTSQASQLND YIAREDSLQP LSLWEFAARA DKVKGRASGF DAESYEEFVD
FDGTEHVQLS VAQRLDQALQ STSKKRPTYS FTAQHEQCTT HMLRIRQPAS AFIPVPVGSI
PRRDREPLYP RYCRLMLIMF KPWKAACDLR EHNESWADAF HRFRETTSCQ HKYMSIIHNM
QLMHECKDHR DEHIASRKNR KPLFSIAPEL TNEDRYSLDD DTLTENISEA DILHHLQLVD
ASHSLAQQSM SNNATACVNY ATIAGLFDVN IPQNIAQEQI EAATEELQPT ESSPLEDEWK
TAYQRRRNRW KMRTTESVND THSPMNSNTY VCSIQDGSAF RNAQTGNSET PLSRIVPGNV
STPTEDNINA DDVSKTWTLN DEQDRAFKLI TNHSLQQNTD EPLRMYIAGP AGTGKTRIIN
AVKDFFEKKQ QARRFRLASY MGIAARNIAG MTLHAALSLG QNQRSNENSK THRDLIAMWE
GVDYLFIDEV SMISCQFLTR ISDALSIAKG NSAPFGGINI IFAGDFAQLP PVKETRLYAK
LKPTTPSSTP YAQKAALGRA LWLSVDTVVI LKTPQRQKGS SNEEFVNLLS RLREGKCTNR
DFNLLNTRVI DSETYPPLST TPWKHAPLIV YDNGTKDAIN AHAAYAFARE SGKCLHWYYA
NDKRRGVSIT DENLTRHLLT YHSGKTNQRL GRIPLVIGMP VIVAQNFDVE GGIVNGSRGT
LSRIRFRINE SNERTLVSVI VNIPDSSDEA MPHLQSHDLP VLPDAVDIKF QHPYNHSTCN
IRRHQVPVLP AFAMTCHRAQ GQSMPRVIVD LQACTGTEAP YVMVSRATSL QGLLILRPFE
KKKITCCQSE DARNETERLW KLSLQTIINT GNENSAQAAR RRLHECTRHN SDSSPKDTTP
RSNWLVRQSL VHEHTPSPVL SPSNVSYANG DEQSARKYIQ NNVLSPADTM SSSYQLTRQP
LVQEHTSSPD PSPSSSSNTD DSEHRLTRQP LEHTSSPDSS SSSPSNTDNS EHISVLHFQL
HRLVHSQNVS SNNAPNSASS GTLSGHNEHT PNDARIRRQP LLYRPAVRGE LVKLSSPFQT
LLRSLLSWQH LPRTQKETKS SSLVSLNRHP FRHRLKLRNS SSTTQPFFPP YLFPTSTMNS
SFDSKCFPER LSSGLYKRLS DQIINAKSSA LANAEYKETF HRDTTDWLKN FNYVDAGGRR
FMPLVFGEVV SSALGTKMSA KGTFFTGGND PKFITDETKV KDVIVLGRPT CATKNLAIQF
NNQIAALNEV FQDDEKRYAG CNEGWNPKEW VRSSGTEDRK ADMLVLTMLP KYTTSNDKAP
KDSTKPRLKR QALDDDSDDL PDAEAGGAPG APSGDGGSLT APPVAPPNVE PKVGDLYDPR
LLPDYGGDLF HHKQSKLIQL DVQNIDEKIV FPWDMYDELR PGTLVIAKTS LHCFWIGQKD
GSMKQFYQIN AHSIKILGKS DLAMEIPSIP DAPRTTKRKA TDPPSHEGDD EAIFSSFSPK
KLRQDTTMDP GSSGIPNATS DRLKSAADPK GKTKVPSTTQ EQRQLWDSLR RARGGIVGSL
ALRLFLHHQP TTWVPNDLNL VAPRNHLYHI NRFLLLKGFI KHRKPNLYPS TIRAHYAYIR
RPTNNTPGYR LITLSETSSS KSVVYSLGDA PSTALMGIVT PSTLLCLYTD LLARRICVNA
NSRTLPLAMI LTLNQRKLIS VRSMGDRRIG MQ
//
